Verification of Brown Adipose Tissue using MRI

Christoph Birkl

Publikation: StudienabschlussarbeitMasterarbeit

Abstract

Recently it has been realized that also adult persons possess brown adipose tissue (BAT). This active fat tissue produces energy and is in an exchange with white adipose tissue (WAT). White and brown adipose tissues have an important role in the energy metabolism and for diseases like obesity or type 2 diabetes. The goal of this project was to evaluate the feasibility of a Magnetic Resonance Imaging (MRI) based method to separate brown and white adipose tissue. To reach this goal a work flow was developed for the image acquisition and an evaluation software tool was implemented.

The experimental set-up included studies with phantoms, animal and human tissue. To separate the adipose tissue a fat fraction image is calculated. For the calculation of the fat fraction a separate water and fat image is determined by using an iterative algorithm (Iterative Decomposition with Echo Asymmetry and Least squares estimation (IDEAL)). The investigation and analysis of young mice revealed the well known BAT depot in the neck of these animals. The present work showed the great potential of the used method to separate adipose tissue and provide ideas for further improvement of the implemented method.
Originalspracheenglisch
QualifikationMaster of Science
Gradverleihende Hochschule
  • Technische Universität Graz (90000)
Betreuer/-in / Berater/-in
  • Stollberger, Rudolf, Betreuer
PublikationsstatusVeröffentlicht - 2012

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