Using oxygen-consuming thermoset plastics to generate hypoxic conditions in microfluidic devices for potential cell culture applications

D. Sticker, M. Rothbauer, J. Ehgartner, C. Steininger, W. Neuhaus, T. Mayr, T. Haraldsson, J.P. Kutter, P. Ertl

Publikation: Beitrag in Buch/Bericht/KonferenzbandBeitrag in einem Konferenzband

Abstract

The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMER TM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.

Originalspracheenglisch
Titel21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Seiten812-813
Seitenumfang2
ISBN (elektronisch)9780692941836
PublikationsstatusVeröffentlicht - 2020
Veranstaltung21st International Conference on Miniaturized Systems for Chemistry and Life Sciences - Savannah, USA / Vereinigte Staaten
Dauer: 22 Okt 201726 Okt 2017

Konferenz

Konferenz21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
KurztitelMicrTAS 2017
LandUSA / Vereinigte Staaten
OrtSavannah
Zeitraum22/10/1726/10/17

Fields of Expertise

  • Human- & Biotechnology

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