Ultra-small dye-doped silica nanoparticles via modified sol-gel technique

R. Riccò, S. Nizzero, E. Penna, A. Meneghello, E. Cretaio, F. Enrichi

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

In modern biosensing and imaging, fluorescence-based methods constitute the most diffused approach to achieve optimal detection of analytes, both in solution and on the single-particle level. Despite the huge progresses made in recent decades in the development of plasmonic biosensors and label-free sensing techniques, fluorescent molecules remain the most commonly used contrast agents to date for commercial imaging and detection methods. However, they exhibit low stability, can be difficult to functionalise, and often result in a low signal-to-noise ratio. Thus, embedding fluorescent probes into robust and bio-compatible materials, such as silica nanoparticles, can substantially enhance the detection limit and dramatically increase the sensitivity. In this work, ultra-small fluorescent silica nanoparticles (NPs) for optical biosensing applications were doped with a fluorescent dye, using simple water-based sol-gel approaches based on the classical Stöber procedure. By systematically modulating reaction parameters, controllable size tuning of particle diameters as low as 10 nm was achieved. Particles morphology and optical response were evaluated showing a possible single-molecule behaviour, without employing microemulsion methods to achieve similar results. [Figure not available: see fulltext.].

Originalspracheenglisch
Aufsatznummer117
FachzeitschriftJournal of Nanoparticle Research
Jahrgang20
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - 1 Mai 2018

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Sol-gel
Dyes
Silica
Fluorescent Dyes
Silicon Dioxide
Sol-gels
Nanoparticles
Biosensing
Coloring Agents
dyes
gels
silicon dioxide
Imaging techniques
nanoparticles
Molecules
Microemulsions
Imaging
Biosensors
Biomaterials
Contrast Media

Schlagwörter

    ASJC Scopus subject areas

    • Bioengineering
    • !!Atomic and Molecular Physics, and Optics
    • !!Chemistry(all)
    • !!Modelling and Simulation
    • !!Materials Science(all)
    • !!Condensed Matter Physics

    Dies zitieren

    Ultra-small dye-doped silica nanoparticles via modified sol-gel technique. / Riccò, R.; Nizzero, S.; Penna, E.; Meneghello, A.; Cretaio, E.; Enrichi, F.

    in: Journal of Nanoparticle Research, Jahrgang 20, Nr. 5, 117, 01.05.2018.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    Riccò, R. ; Nizzero, S. ; Penna, E. ; Meneghello, A. ; Cretaio, E. ; Enrichi, F. / Ultra-small dye-doped silica nanoparticles via modified sol-gel technique. in: Journal of Nanoparticle Research. 2018 ; Jahrgang 20, Nr. 5.
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    AU - Penna, E.

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    AU - Cretaio, E.

    AU - Enrichi, F.

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