Type, density, and location of immune cells within human colorectal tumors predicts clinical outcome.

Jérôme Galon; A. Costes; Fátima Sánchez Cabo; A. Kirilovsky; Bernhard Mlecnik; Christine Lagorce-Pagès; Marie Tosolini; Matthieu Camus; Anne Berger; Philippe Wind; Franck Zinzindohoué; P. Bruneval; Paul-Henri Cugnenc; Zlatko Trajanoski; Wolf-Herman Fridman; Franck Pagès

doi:10.1126/science.1129139

Type, density, and location of immune cells within human colorectal tumors predicts clinical outcome.

Jérôme Galon^*, A. Costes, Fátima Sánchez Cabo, A. Kirilovsky, Bernhard Mlecnik, Christine Lagorce-Pagès, Marie Tosolini, Matthieu Camus, Anne Berger, Philippe Wind, Franck Zinzindohoué, P. Bruneval, Paul-Henri Cugnenc, Zlatko Trajanoski, Wolf-Herman Fridman, Franck Pagès

^*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies

Originalsprache	englisch
Seiten (von - bis)	1960-1964
Fachzeitschrift	Science
Jahrgang	313
Ausgabenummer	5795
DOIs	https://doi.org/10.1126/science.1129139
Publikationsstatus	Veröffentlicht - 2006

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Zugriff auf Dokument

10.1126/science.1129139

Dieses zitieren

Galon, J., Costes, A., Sánchez Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., Zinzindohoué, F., Bruneval, P., Cugnenc, P.-H., Trajanoski, Z., Fridman, W.-H., & Pagès, F. (2006). Type, density, and location of immune cells within human colorectal tumors predicts clinical outcome. Science, 313(5795), 1960-1964. https://doi.org/10.1126/science.1129139

Galon, J, Costes, A, Sánchez Cabo, F, Kirilovsky, A, Mlecnik, B, Lagorce-Pagès, C, Tosolini, M, Camus, M, Berger, A, Wind, P, Zinzindohoué, F, Bruneval, P, Cugnenc, P-H, Trajanoski, Z, Fridman, W-H & Pagès, F 2006, 'Type, density, and location of immune cells within human colorectal tumors predicts clinical outcome.', Science, Jg. 313, Nr. 5795, S. 1960-1964. https://doi.org/10.1126/science.1129139

@article{4fc65497ab3549a28908a90a44101123,

title = "Type, density, and location of immune cells within human colorectal tumors predicts clinical outcome.",

abstract = "The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies",

author = "J{\'e}r{\^o}me Galon and A. Costes and {S{\'a}nchez Cabo}, F{\'a}tima and A. Kirilovsky and Bernhard Mlecnik and Christine Lagorce-Pag{\`e}s and Marie Tosolini and Matthieu Camus and Anne Berger and Philippe Wind and Franck Zinzindohou{\'e} and P. Bruneval and Paul-Henri Cugnenc and Zlatko Trajanoski and Wolf-Herman Fridman and Franck Pag{\`e}s",

year = "2006",

doi = "10.1126/science.1129139",

language = "English",

volume = "313",

pages = "1960--1964",

journal = "Science",

issn = "1095-9203",

publisher = "American Association for the Advancement of Science",

number = "5795",

}

TY - JOUR

T1 - Type, density, and location of immune cells within human colorectal tumors predicts clinical outcome.

AU - Galon, Jérôme

AU - Costes, A.

AU - Sánchez Cabo, Fátima

AU - Kirilovsky, A.

AU - Mlecnik, Bernhard

AU - Lagorce-Pagès, Christine

AU - Tosolini, Marie

AU - Camus, Matthieu

AU - Berger, Anne

AU - Wind, Philippe

AU - Zinzindohoué, Franck

AU - Bruneval, P.

AU - Cugnenc, Paul-Henri

AU - Trajanoski, Zlatko

AU - Fridman, Wolf-Herman

AU - Pagès, Franck

PY - 2006

Y1 - 2006

N2 - The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies

AB - The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies

U2 - 10.1126/science.1129139

DO - 10.1126/science.1129139

M3 - Article

SN - 1095-9203

VL - 313

SP - 1960

EP - 1964

JO - Science

JF - Science

IS - 5795

ER -

Type, density, and location of immune cells within human colorectal tumors predicts clinical outcome.

Abstract

UN SDGs

Zugriff auf Dokument

Fingerprint

Dieses zitieren