TY - JOUR
T1 - Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate
AU - Zellnitz, Sarah
AU - Pinto, Joana
AU - Brunsteiner, Michael
AU - Schröttner, Hartmuth
AU - Khinast, Johannes
AU - Paudel, Amrit
PY - 2019
Y1 - 2019
N2 - PurposeThe performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery.MethodsSalbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe.ResultsThe spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet milled SBS (crystalline and acicular) that charged negatively and to a lower extent. D-mannitol charged positively and to a higher extent than the APIs. All drug-excipient blends charged negatively and differences were found between the spray-dried and jet milled SBS blends at 2% and 5% drug loads.ConclusionsIt was demonstrated how distinct solid-states, particle shape, size and morphology as well as different water contents of the different materials can affect tribo-charging. For their binary blends, the amount and nature of fines seem to govern inter-particle contacts critically impacting charge evolution.
AB - PurposeThe performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery.MethodsSalbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe.ResultsThe spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet milled SBS (crystalline and acicular) that charged negatively and to a lower extent. D-mannitol charged positively and to a higher extent than the APIs. All drug-excipient blends charged negatively and differences were found between the spray-dried and jet milled SBS blends at 2% and 5% drug loads.ConclusionsIt was demonstrated how distinct solid-states, particle shape, size and morphology as well as different water contents of the different materials can affect tribo-charging. For their binary blends, the amount and nature of fines seem to govern inter-particle contacts critically impacting charge evolution.
KW - dry powder inhaler (DPI)
KW - inhalation
KW - particle/material properties
KW - powder blends
KW - powder processing
KW - Dry Powder Inhalers
KW - Excipients/chemistry
KW - Humans
KW - Administration, Inhalation
KW - Particle Size
KW - Powders/chemistry
KW - Drug Carriers/chemistry
KW - Surface Properties
KW - Chemistry, Pharmaceutical/methods
KW - Albuterol/administration & dosage
KW - Mannitol/chemistry
KW - dry powder inhaler(DPI)
UR - http://www.scopus.com/inward/record.url?scp=85064182458&partnerID=8YFLogxK
U2 - 10.1007/s11095-019-2612-9
DO - 10.1007/s11095-019-2612-9
M3 - Article
SN - 1573-904X
VL - 36
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 6
M1 - 80
ER -