The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes

Sarfraz Ahmad, Werner Seebacher, Johanna Faist, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

3-Azabicyclo[3.2.2]nonanes are already reported as antiprotozoal agents. Structural variations were performed by attachment of several basic side chains, being part of drugs in use, to the ring nitrogen. The structures of the new compounds were established using one and two dimensional NMR measurements. All compounds were investigated for their antiplasmodial and antitrypanosomal activities against Plasmodium falciparum K 1 (multiresistant) and Trypanosoma brucei rhodesiense. Their cytotoxicity was assessed against L6 cells. The results are compared to the activities of formerly synthesized compounds. Structure–activity relationships are discussed.
Originalspracheenglisch
Seiten (von - bis)1391-1403
FachzeitschriftArchives of Pharmacal Research
Jahrgang39
Ausgabenummer10
DOIs
PublikationsstatusVeröffentlicht - 2016

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)

Fingerprint

Untersuchen Sie die Forschungsthemen von „The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes“. Zusammen bilden sie einen einzigartigen Fingerprint.
  • Massenspektrometrie

    Saf, R. & Bartl, K.

    1/01/95 → …

    Projekt: Arbeitsgebiet

Dieses zitieren