Abstract
Abstract: Modified 1,5-dideoxy-1,5-imino-d-xylitol analogues with different substitution patterns involving position C-1 and/or the ring nitrogen were prepared, which were designed to serve as precursors for the preparation of iminoxylitol-based ligands and tools for the elucidation and modulation of human lysosomal β-glucocerebrosidase. Biological evaluation of the synthesized glycomimetics with a series of glycoside hydrolases revealed that these substitution patterns elicit excellent β-glucosidase selectivities. Graphical abstract: [Figure not available: see fulltext.].
Originalsprache | englisch |
---|---|
Seiten (von - bis) | 831-842 |
Seitenumfang | 12 |
Fachzeitschrift | Monatshefte für Chemie - Chemical Monthly |
Jahrgang | 150 |
Ausgabenummer | 5 |
DOIs | |
Publikationsstatus | Veröffentlicht - 2019 |
ASJC Scopus subject areas
- Chemie (insg.)