Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis

Martina Korber; Isabella Klein; Günther Daum

doi:10.1016/j.bbalip.2017.09.002

Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis

Martina Korber, Isabella Klein, Günther Daum^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Biochemie (6480)

Publikation: Beitrag in einer Fachzeitschrift › Review eines Fachbereichs (Review article) › Begutachtung

Abstract

Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.

Originalsprache	englisch
Seiten (von - bis)	1534-1545
Seitenumfang	12
Fachzeitschrift	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Jahrgang	1862
Ausgabenummer	12
DOIs	https://doi.org/10.1016/j.bbalip.2017.09.002
Publikationsstatus	Veröffentlicht - 1 Dez. 2017

ASJC Scopus subject areas

Molekularbiologie
Zellbiologie

Kooperationen

NAWI Graz

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Zugriff auf Dokument

10.1016/j.bbalip.2017.09.002

Andere Dateien und Links

http://www.scopus.com/inward/record.url?scp=85029476624&partnerID=8YFLogxK

Dieses zitieren

@article{e431ff1004d1416b80848194eadf33f9,

title = "Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis",

abstract = "Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.",

keywords = "Lipid droplet, Sterol homeostasis, Steryl ester hydrolase, Steryl ester synthase",

author = "Martina Korber and Isabella Klein and G{\"u}nther Daum",

year = "2017",

month = dec,

day = "1",

doi = "10.1016/j.bbalip.2017.09.002",

language = "English",

volume = "1862",

pages = "1534--1545",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

issn = "1388-1981",

publisher = "Elsevier B.V.",

number = "12",

}

TY - JOUR

T1 - Steryl ester synthesis, storage and hydrolysis

T2 - A contribution to sterol homeostasis

AU - Korber, Martina

AU - Klein, Isabella

AU - Daum, Günther

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.

AB - Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.

KW - Lipid droplet

KW - Sterol homeostasis

KW - Steryl ester hydrolase

KW - Steryl ester synthase

UR - http://www.scopus.com/inward/record.url?scp=85029476624&partnerID=8YFLogxK

U2 - 10.1016/j.bbalip.2017.09.002

DO - 10.1016/j.bbalip.2017.09.002

M3 - Review article

C2 - 28888831

AN - SCOPUS:85029476624

SN - 1388-1981

VL - 1862

SP - 1534

EP - 1545

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 12

ER -

Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis

Abstract

ASJC Scopus subject areas

Kooperationen

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren