STDP forms associations between memory traces in networks of spiking neurons

Christoph Pokorny, Matias J. Ison, Arjun Rao, Robert Legenstein, Wolfgang Maass, Christos Papadimitriou

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

Memory traces and associations between them are fundamental for cognitive brain function. Neuron recordings suggest that distributed assemblies of neurons in the brain serve as memory traces for spatial information, real-world items, and concepts. However, there is conflicting evidence regarding neural codes for associated memory traces. Some studies suggest the emergence of overlaps between assemblies during an association, while others suggest that the assemblies themselves remain largely unchanged and new assemblies emerge as neural codes for associated memory items. Here we study the emergence of neural codes for associated memory items in a generic computational model of recurrent networks of spiking neurons with a data-constrained rule for spike-timing-dependent plasticity. The model depends critically on 2 parameters, which control the excitability of neurons and the scale of initial synaptic weights. By modifying these 2 parameters, the model can reproduce both experimental data from the human brain on the fast formation of associations through emergent overlaps between assemblies, and rodent data where new neurons are recruited to encode the associated memories. Hence, our findings suggest that the brain can use both of these 2 neural codes for associations, and dynamically switch between them during consolidation.

Originalspracheenglisch
Seiten (von - bis)952-968
Seitenumfang17
FachzeitschriftCerebral Cortex
Jahrgang30
Ausgabenummer3
DOIs
PublikationsstatusVeröffentlicht - Mär 2020

ASJC Scopus subject areas

  • Zelluläre und Molekulare Neurowissenschaften
  • Kognitive Neurowissenschaft

Fingerprint

Untersuchen Sie die Forschungsthemen von „STDP forms associations between memory traces in networks of spiking neurons“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren