Solvent‐ and Catalyst‐Free Aza‐Michael Addition of Imidazoles and Related Heterocycles

Katharina Kodolitsch, Florian Gobec, Christian Slugovc*

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikel

Abstract

This work demonstrates the scope and limitations of the aza-Michael addition of imidazoles and related heterocycles with electron deficient olefins under solvent- and catalyst-free conditions. The reaction proceeds at 80 °C within hours towards completion as long as the azole derivative is sufficiently soluble in the Michael acceptor, which has been used in small excess. Workup only comprises evaporation of surplus Michael-acceptor, and no additional solvents are necessary for purifying the products.

Originalspracheenglisch
Seiten (von - bis)2973-2978
Seitenumfang6
FachzeitschriftEuropean Journal of Organic Chemistry
Jahrgang2020
Ausgabenummer19
DOIs
PublikationsstatusVeröffentlicht - 22 Mai 2020

ASJC Scopus subject areas

  • !!Physical and Theoretical Chemistry
  • Organische Chemie

Fields of Expertise

  • Advanced Materials Science

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