Signal enhancement in DNA microarray using dye doped silica nanoparticles: Application to Human Papilloma Virus (HPV) detection

Raffaele Riccò, Anna Meneghello, Francesco Enrichi

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

DNA microarray is a powerful tool for the parallel of nucleic acids and other biologically significant molecules. In this communication we report an easy and cheap synthesis route for incorporating organic dyes into monodisperse inorganic silica nanoparticles and their application on the detection of carcinogenic risky Human Papilloma Virus using DNA microarray technology. We correlate our system with conventional direct dyes and commercial quantum dots, with a promising increase in optical signal, and a related decrease of the limit of detection, thus giving a remarkable improvement in this technique towards early diagnosis of diseases and trace level detection of dangerous biological contaminants.

Originalspracheenglisch
Seiten (von - bis)2761-2765
Seitenumfang5
FachzeitschriftBiosensors & Bioelectronics
Jahrgang26
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - 15 Jan 2011
Extern publiziertJa

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Papillomaviridae
Microarrays
Oligonucleotide Array Sequence Analysis
Viruses
Silicon Dioxide
Nanoparticles
DNA
Coloring Agents
Dyes
Silica
Quantum Dots
Nucleic acids
Nucleic Acids
Semiconductor quantum dots
Limit of Detection
Early Diagnosis
Impurities
Technology
Molecules
Communication

Schlagwörter

    ASJC Scopus subject areas

    • !!Biophysics
    • !!Biomedical Engineering
    • Biotechnology
    • !!Electrochemistry

    Dies zitieren

    Signal enhancement in DNA microarray using dye doped silica nanoparticles : Application to Human Papilloma Virus (HPV) detection. / Riccò, Raffaele; Meneghello, Anna; Enrichi, Francesco.

    in: Biosensors & Bioelectronics, Jahrgang 26, Nr. 5, 15.01.2011, S. 2761-2765.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

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