R1 dispersion contrast at high field with fast field-cycling MRI

Markus Bödenler, Martina Basini, Maria Francesca Casula, Evrim Umut, Christian Gösweiner, Andreas Petrovic, Danuta Kruk, Hermann Scharfetter

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Contrast agents with a strong R1 dispersion have been shown to be effective in generating target-specific contrast in MRI. The utilization of this R1 field dependence requires the adaptation of an MRI scanner for fast field-cycling (FFC). Here, we present the first implementation and validation of FFC-MRI at a clinical field strength of 3 T. A field-cycling range of ±100 mT around the nominal B0 field was realized by inserting an additional insert coil into an otherwise conventional MRI system. System validation was successfully performed with selected iron oxide magnetic nanoparticles and comparison to FFC-NMR relaxometry measurements. Furthermore, we show proof-of-principle R1 dispersion imaging and demonstrate the capability of generating R1 dispersion contrast at high field with suppressed background signal. With the presented ready-to-use hardware setup it is possible to investigate MRI contrast agents with a strong R1 dispersion at a field strength of 3 T.

Originalspracheenglisch
Seiten (von - bis)68-75
Seitenumfang8
FachzeitschriftJournal of magnetic resonance
Jahrgang290
DOIs
PublikationsstatusVeröffentlicht - 1 Mai 2018

Fingerprint

Magnetic resonance imaging
Contrast Media
cycles
Nanoparticles
field strength
inserts
iron oxides
scanners
hardware
coils
nanoparticles
nuclear magnetic resonance
Nuclear magnetic resonance
Hardware
Imaging techniques
ferric oxide

Schlagwörter

    ASJC Scopus subject areas

    • !!Biophysics
    • !!Biochemistry
    • !!Nuclear and High Energy Physics
    • !!Condensed Matter Physics

    Dies zitieren

    R1 dispersion contrast at high field with fast field-cycling MRI. / Bödenler, Markus; Basini, Martina; Casula, Maria Francesca; Umut, Evrim; Gösweiner, Christian; Petrovic, Andreas; Kruk, Danuta; Scharfetter, Hermann.

    in: Journal of magnetic resonance, Jahrgang 290, 01.05.2018, S. 68-75.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    Bödenler, Markus ; Basini, Martina ; Casula, Maria Francesca ; Umut, Evrim ; Gösweiner, Christian ; Petrovic, Andreas ; Kruk, Danuta ; Scharfetter, Hermann. / R1 dispersion contrast at high field with fast field-cycling MRI. in: Journal of magnetic resonance. 2018 ; Jahrgang 290. S. 68-75.
    @article{b32ec510b9884f0f90ffbda0b88907ce,
    title = "R1 dispersion contrast at high field with fast field-cycling MRI",
    abstract = "Contrast agents with a strong R1 dispersion have been shown to be effective in generating target-specific contrast in MRI. The utilization of this R1 field dependence requires the adaptation of an MRI scanner for fast field-cycling (FFC). Here, we present the first implementation and validation of FFC-MRI at a clinical field strength of 3 T. A field-cycling range of ±100 mT around the nominal B0 field was realized by inserting an additional insert coil into an otherwise conventional MRI system. System validation was successfully performed with selected iron oxide magnetic nanoparticles and comparison to FFC-NMR relaxometry measurements. Furthermore, we show proof-of-principle R1 dispersion imaging and demonstrate the capability of generating R1 dispersion contrast at high field with suppressed background signal. With the presented ready-to-use hardware setup it is possible to investigate MRI contrast agents with a strong R1 dispersion at a field strength of 3 T.",
    keywords = "Contrast agent, Delta relaxation enhanced MR, Dispersion, Fast field-cycling, MRI, Quadrupole relaxation enhancement",
    author = "Markus B{\"o}denler and Martina Basini and Casula, {Maria Francesca} and Evrim Umut and Christian G{\"o}sweiner and Andreas Petrovic and Danuta Kruk and Hermann Scharfetter",
    year = "2018",
    month = "5",
    day = "1",
    doi = "10.1016/j.jmr.2018.03.010",
    language = "English",
    volume = "290",
    pages = "68--75",
    journal = "Journal of magnetic resonance",
    issn = "1090-7807",
    publisher = "Academic Press",

    }

    TY - JOUR

    T1 - R1 dispersion contrast at high field with fast field-cycling MRI

    AU - Bödenler, Markus

    AU - Basini, Martina

    AU - Casula, Maria Francesca

    AU - Umut, Evrim

    AU - Gösweiner, Christian

    AU - Petrovic, Andreas

    AU - Kruk, Danuta

    AU - Scharfetter, Hermann

    PY - 2018/5/1

    Y1 - 2018/5/1

    N2 - Contrast agents with a strong R1 dispersion have been shown to be effective in generating target-specific contrast in MRI. The utilization of this R1 field dependence requires the adaptation of an MRI scanner for fast field-cycling (FFC). Here, we present the first implementation and validation of FFC-MRI at a clinical field strength of 3 T. A field-cycling range of ±100 mT around the nominal B0 field was realized by inserting an additional insert coil into an otherwise conventional MRI system. System validation was successfully performed with selected iron oxide magnetic nanoparticles and comparison to FFC-NMR relaxometry measurements. Furthermore, we show proof-of-principle R1 dispersion imaging and demonstrate the capability of generating R1 dispersion contrast at high field with suppressed background signal. With the presented ready-to-use hardware setup it is possible to investigate MRI contrast agents with a strong R1 dispersion at a field strength of 3 T.

    AB - Contrast agents with a strong R1 dispersion have been shown to be effective in generating target-specific contrast in MRI. The utilization of this R1 field dependence requires the adaptation of an MRI scanner for fast field-cycling (FFC). Here, we present the first implementation and validation of FFC-MRI at a clinical field strength of 3 T. A field-cycling range of ±100 mT around the nominal B0 field was realized by inserting an additional insert coil into an otherwise conventional MRI system. System validation was successfully performed with selected iron oxide magnetic nanoparticles and comparison to FFC-NMR relaxometry measurements. Furthermore, we show proof-of-principle R1 dispersion imaging and demonstrate the capability of generating R1 dispersion contrast at high field with suppressed background signal. With the presented ready-to-use hardware setup it is possible to investigate MRI contrast agents with a strong R1 dispersion at a field strength of 3 T.

    KW - Contrast agent

    KW - Delta relaxation enhanced MR

    KW - Dispersion

    KW - Fast field-cycling

    KW - MRI

    KW - Quadrupole relaxation enhancement

    UR - http://www.scopus.com/inward/record.url?scp=85044158255&partnerID=8YFLogxK

    U2 - 10.1016/j.jmr.2018.03.010

    DO - 10.1016/j.jmr.2018.03.010

    M3 - Article

    VL - 290

    SP - 68

    EP - 75

    JO - Journal of magnetic resonance

    JF - Journal of magnetic resonance

    SN - 1090-7807

    ER -