Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Alhosna Benjdia; Korbinian Heil; Andreas Winkler; Thomas Carell; Ilme Schlichting

doi:10.1039/c4cc05158k

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Alhosna Benjdia^*, Korbinian Heil, Andreas Winkler, Thomas Carell, Ilme Schlichting

^*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.

Originalsprache	englisch
Seiten (von - bis)	14201-14204
Fachzeitschrift	Chemical Communications
Jahrgang	50
DOIs	https://doi.org/10.1039/c4cc05158k
Publikationsstatus	Veröffentlicht - 2014
Extern publiziert	Ja

Fields of Expertise

Human- & Biotechnology

Treatment code (Nähere Zuordnung)

Basic - Fundamental (Grundlagenforschung)

Zugriff auf Dokument

10.1039/c4cc05158k

Dieses zitieren

@article{357c8f3e90ac4d4cb40ec11eb23bbe15,

title = "Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase",

abstract = "The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.",

author = "Alhosna Benjdia and Korbinian Heil and Andreas Winkler and Thomas Carell and Ilme Schlichting",

year = "2014",

doi = "10.1039/c4cc05158k",

language = "English",

volume = "50",

pages = "14201--14204",

journal = "Chemical Communications",

issn = "1364-548X",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

AU - Benjdia, Alhosna

AU - Heil, Korbinian

AU - Winkler, Andreas

AU - Carell, Thomas

AU - Schlichting, Ilme

PY - 2014

Y1 - 2014

N2 - The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.

AB - The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.

U2 - 10.1039/c4cc05158k

DO - 10.1039/c4cc05158k

M3 - Article

SN - 1364-548X

VL - 50

SP - 14201

EP - 14204

JO - Chemical Communications

JF - Chemical Communications

ER -

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Abstract

Fields of Expertise

Treatment code (Nähere Zuordnung)

Zugriff auf Dokument

Fingerprint

Dieses zitieren