TY - JOUR
T1 - Recovery of cis,cis-muconic acid from organic phase after reactive extraction
AU - Gorden, Jannick
AU - Zeiner, Tim
AU - Sadowski, Gabriele
AU - Brandenbusch, Christoph
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Reactive extraction has been shown as an applicable first step in the downstream processing for the recovery of dicarboxylic acids from aqueous solutions, leading to yields of XRE = 0.95 ± 0.05 for cis,cis-muconic acid. A next step towards a downstream processing concept is the examination of strategies to recover the dicarboxylic acid from the organic phase. A reasonable strategy has to lead to high yields and allow for a recycle of the organic phase for further reactive extraction steps. This work presents two recovery strategies for the cis,cis-muconic acid after reactive extraction. A pH-shift uses the strong pH dependency of the reactive extraction itself. A buffered aqueous phase as re-extraction phase leads to a yield of XREEX = 0.99 ± 0.080 at pH > 7. The second approach is the addition of water soluble amines as an additional reactive component. A complex of water soluble amines and the acid is re-extracted into an aqueous phase. Propylamine showed the best performance (XREEX = 1 ± 0.069) of all water soluble amines investigated. An analysis of the distribution behavior of the water soluble amines showed that a recycle of the organic phase for further reactive extraction steps is feasible for both strategies. The results allow for a further development of an in situ downstream processing concept for biocatalytic produced dicarboxylic acids.
AB - Reactive extraction has been shown as an applicable first step in the downstream processing for the recovery of dicarboxylic acids from aqueous solutions, leading to yields of XRE = 0.95 ± 0.05 for cis,cis-muconic acid. A next step towards a downstream processing concept is the examination of strategies to recover the dicarboxylic acid from the organic phase. A reasonable strategy has to lead to high yields and allow for a recycle of the organic phase for further reactive extraction steps. This work presents two recovery strategies for the cis,cis-muconic acid after reactive extraction. A pH-shift uses the strong pH dependency of the reactive extraction itself. A buffered aqueous phase as re-extraction phase leads to a yield of XREEX = 0.99 ± 0.080 at pH > 7. The second approach is the addition of water soluble amines as an additional reactive component. A complex of water soluble amines and the acid is re-extracted into an aqueous phase. Propylamine showed the best performance (XREEX = 1 ± 0.069) of all water soluble amines investigated. An analysis of the distribution behavior of the water soluble amines showed that a recycle of the organic phase for further reactive extraction steps is feasible for both strategies. The results allow for a further development of an in situ downstream processing concept for biocatalytic produced dicarboxylic acids.
KW - cis,cis-muconic acid
KW - Downstream processing
KW - Re-extraction
KW - Reactive extraction
KW - Recovery
UR - http://www.scopus.com/inward/record.url?scp=84973901406&partnerID=8YFLogxK
U2 - 10.1016/j.seppur.2016.05.032
DO - 10.1016/j.seppur.2016.05.032
M3 - Article
AN - SCOPUS:84973901406
SN - 1383-5866
VL - 169
SP - 1
EP - 8
JO - Separation and Purification Technology
JF - Separation and Purification Technology
ER -