Polymorphic mutation frequencies of clinical and environmental Stenotrophomonas maltophilia populations

M.C. Turrientes, M.R. Baquero, M.B. Sánchez, S. Valdezate, E. Escudero, Gabriele Berg, R. Cantón, F. Baquero, J.C. Galán, J.L. Martínez

Publikation: Beitrag in einer FachzeitschriftArtikel

Abstract

Mutation frequencies were studied in 174 Stenotrophomonas maltophilia isolates from clinical and nonclinical environments by detecting spontaneous rifampin-resistant mutants in otherwise-susceptible populations. The distribution of mutation frequencies followed a pattern similar to that found for other bacterial species, with a modal value of 1 × 10−8. Nevertheless, the proportion of isolates showing mutation frequencies below the modal value (hypomutators) was significantly higher for S. maltophilia than those so far reported in other organisms. Low mutation frequencies were particularly frequent among environmental S. maltophilia strains (58.3%), whereas strong mutators were found only among isolates with a clinical origin. These results indicate that clinical environments might select bacterial populations with high mutation frequencies, likely by second-order selection processes. In several of the strong …
Originalspracheenglisch
Seiten (von - bis)1746-1758
FachzeitschriftApplied and Environmental Microbiology
Jahrgang76
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - 2010

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)

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