Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model

Mauro Moglianetti*, Elisa De Luca, Deborah Pedone, Roberto Marotta, Tiziano Catelani, Barbara Sartori, Heinz Amenitsch, Saverio Francesco Retta, Pier Paolo Pompa

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikel

Abstract

In recent years, the use of nanomaterials as biomimetic enzymes has attracted great interest. In this work, we show the potential of biocompatible platinum nanoparticles (Pt NPs) as antioxidant nanozymes, which combine abundant cellular internalization and efficient scavenging activity of cellular reactive oxygen species (ROS), thus simultaneously integrating the functions of nanocarriers and antioxidant drugs. Careful toxicity assessment and intracellular tracking of Pt NPs proved their cytocompatibility and high cellular uptake, with compartmentalization within the endo/lysosomal vesicles. We have demonstrated that Pt NPs possess strong and broad antioxidant properties, acting as superoxide dismutase, catalase, and peroxidase enzymes, with similar or even superior performance than natural enzymes, along with higher adaptability to the changes in environmental conditions. We then exploited their potent activity as radical scavenging materials in a cellular model of an oxidative stress-related disorder, namely human Cerebral Cavernous Malformation (CCM) disease, which is associated with a significant increase in intracellular ROS levels. Noteworthily, we found that Pt nanozymes can efficiently reduce ROS levels, completely restoring the cellular physiological homeostasis.

Originalspracheenglisch
Seiten (von - bis)3739-3752
Seitenumfang14
FachzeitschriftNanoscale
Jahrgang8
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - 14 Feb 2016

ASJC Scopus subject areas

  • !!Materials Science(all)

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