Photo-Biocatalysis: Biotransformations in the Presence of Light

Luca Schmermund, Valentina Jurkaš, Fatma Feyza Özgen, Giovanni Davide Barone, Hanna Christiane Büchsenschütz, Christoph K. Winkler, S Schmidt, Robert Kourist, Wolfgang Kroutil

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)Begutachtung

Abstract

Light has received increased attention for various chemical reactions but also in combination with biocatalytic reactions. Because currently only a few enzymatic reactions are known, which per se require light, most transformations involving light and a biocatalyst exploit light either for providing the cosubstrate or cofactor in an appropriate redox state for the biotransformation. In selected cases, a promiscuous activity of known enzymes in the presence of light could be induced. In other approaches, light-induced chemical reactions have been combined with a biocatalytic step, or light-induced biocatalytic reactions were combined with chemical reactions in a linear cascade. Finally, enzymes with a light switchable moiety have been investigated to turn off/on or tune the actual reaction. This Review gives an overview of the various approaches for using light in biocatalysis.

Originalspracheenglisch
Seiten (von - bis)4115-4144
Seitenumfang30
FachzeitschriftACS Catalysis
Jahrgang9
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - 2019

ASJC Scopus subject areas

  • Chemie (insg.)
  • Katalyse

Kooperationen

  • NAWI Graz

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