Pharmaceutical-grade oral films as substrates for printed medicine

Miriam Wimmer-Teubenbacher, Carole Planchette, Heinz Pichler, Daniel Markl, Wen Kai Hsiao, Amrit Paudel, Sven Stegemann

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them
Originalspracheenglisch
Seiten (von - bis)169-180
Seitenumfang12
FachzeitschriftInternational Journal of Pharmaceutics
Jahrgang547
Ausgabenummer1-2
DOIs
PublikationsstatusVeröffentlicht - 2018

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Printing
Medicine
Pharmaceutical Preparations
Polymers
Polarization Microscopy
Drug Compounding
Ink
Differential Scanning Calorimetry
Dosage Forms
Optical Coherence Tomography
Drug Interactions
Electron Scanning Microscopy
Spectrum Analysis
X-Rays
picosulfate sodium

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    Pharmaceutical-grade oral films as substrates for printed medicine. / Wimmer-Teubenbacher, Miriam; Planchette, Carole; Pichler, Heinz; Markl, Daniel; Hsiao, Wen Kai; Paudel, Amrit; Stegemann, Sven.

    in: International Journal of Pharmaceutics, Jahrgang 547, Nr. 1-2, 2018, S. 169-180.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

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    abstract = "In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them",
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    AU - Planchette, Carole

    AU - Pichler, Heinz

    AU - Markl, Daniel

    AU - Hsiao, Wen Kai

    AU - Paudel, Amrit

    AU - Stegemann, Sven

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