Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process

Titel in Übersetzung: Optische Kohärenz Tomographie (OCT) zur Echtzeit-Analyse der Coating-Variabilität eines kontinuierlichen Coating Prozesses

Matthias Wolfgang, Patrick Wahl, Manuel Zettl, Stephan Sacher, Johannes G. Khinast, Rainer Bastian, Thomas Fränkel

Publikation: Konferenzbeitrag(Altdaten) Vortrag oder Präsentation

Abstract

This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner.
OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.
Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.
Originalspracheenglisch
PublikationsstatusVeröffentlicht - 17 Nov 2016
VeranstaltungAIChE Annual Meeting 2016 - Hilton, San Francisco, USA / Vereinigte Staaten
Dauer: 14 Nov 201619 Nov 2016

Konferenz

KonferenzAIChE Annual Meeting 2016
LandUSA / Vereinigte Staaten
OrtSan Francisco
Zeitraum14/11/1619/11/16

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  • Dieses zitieren

    Wolfgang, M., Wahl, P., Zettl, M., Sacher, S., Khinast, J. G., Bastian, R., & Fränkel , T. (2016). Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process. AIChE Annual Meeting 2016, San Francisco, USA / Vereinigte Staaten.