Abstract
Within this study, we investigated a one-pot enzymatic redox cascade composed of different enoate reductases (5 EREDs from diverse bacterial origins) and various Baeyer-Villiger monooxygenases (4 BVMOs) with complementary regioselectivity that enabled access to six out of eight carvo-lactone stereoisomers starting from readily available natural carvones. Applicability of this two-step cascade was demonstrated by preparative scale experiments yielding up to 76% of the desired chiral carvolactone.
Originalsprache | englisch |
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Seiten (von - bis) | 7389-7394 |
Seitenumfang | 6 |
Fachzeitschrift | Tetrahedron |
Jahrgang | 74 |
Ausgabenummer | 52 |
DOIs | |
Publikationsstatus | Veröffentlicht - 27 Dez. 2018 |
ASJC Scopus subject areas
- Biochemie
- Wirkstoffforschung
- Organische Chemie