Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments

Carlos G. Acevedo-Rocha*, Michael G. Hoesl, Sebastian Nehring, Marina Royter, Christina Wolschner, Birgit Wiltschi, Garabed Antranikian, Nediljko Budisa

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to 450%) and surfactants (resp. 1630%), but also protective effects against protein reducing (resp. 140%), alkylating (resp. 160%), and denaturing (resp.190%) agents as well as inhibitors (resp. 40%). This approach offers novel chemically diversified biocatalysts for hostile environments.

Originalspracheenglisch
Seiten (von - bis)1198-1201
Seitenumfang4
FachzeitschriftCatalysis Science and Technology
Jahrgang3
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - 1 Mai 2013

ASJC Scopus subject areas

  • Katalyse

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