Abstract
A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose via a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained N-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was N-alkylated to furnish a set of potential α-galactosidase inhibitors. Their glycosidase inhibitory activities were screened with a panel of standard glycosidases of biological significance.
Originalsprache | englisch |
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Seiten (von - bis) | 15943-15951 |
Seitenumfang | 9 |
Fachzeitschrift | RSC Advances |
Jahrgang | 11 |
Ausgabenummer | 26 |
DOIs | |
Publikationsstatus | Veröffentlicht - 22 Apr. 2021 |
ASJC Scopus subject areas
- Allgemeine chemische Verfahrenstechnik
- Allgemeine Chemie