@inproceedings{37c3a10dec714bb4ad13fcac8bd404a8,
title = "Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates",
abstract = "We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.",
author = "Alberto Bonisoli and Attilio Marino and Gianni Ciofani and Francesco Greco",
year = "2015",
month = jan,
day = "1",
doi = "10.1557/opl.2015.558",
language = "English",
series = "Materials Research Society Symposium Proceedings",
publisher = "Materials Research Society",
pages = "13--18",
editor = "Jonathan Rivnay and Wallace, {Gordon G.} and Christopher Bettinger and Ng, {Tse Nga}",
booktitle = "Organic Bioelectronics - Materials, Processes and Applications",
address = "United States",
note = "2015 MRS Spring Meeting ; Conference date: 06-04-2015 Through 10-04-2015",
}