Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates

Alberto Bonisoli, Attilio Marino, Gianni Ciofani, Francesco Greco

Publikation: Beitrag in Buch/Bericht/KonferenzbandBeitrag in einem Konferenzband

Abstract

We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.

Originalspracheenglisch
TitelOrganic Bioelectronics - Materials, Processes and Applications
Redakteure/-innenJonathan Rivnay, Gordon G. Wallace, Christopher Bettinger, Tse Nga Ng
Herausgeber (Verlag)Materials Research Society
Seiten13-18
Seitenumfang6
ISBN (elektronisch)9781510826489
DOIs
PublikationsstatusVeröffentlicht - 1 Jan 2015
Extern publiziertJa
Veranstaltung2015 MRS Spring Meeting - San Francisco, USA / Vereinigte Staaten
Dauer: 6 Apr 201510 Apr 2015

Publikationsreihe

NameMaterials Research Society Symposium Proceedings
Band1795
ISSN (Print)0272-9172

Konferenz

Konferenz2015 MRS Spring Meeting
LandUSA / Vereinigte Staaten
OrtSan Francisco
Zeitraum6/04/1510/04/15

ASJC Scopus subject areas

  • !!Materials Science(all)
  • !!Condensed Matter Physics
  • !!Mechanics of Materials
  • !!Mechanical Engineering

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