Monitoring tissue oxygen heterogeneities and their influence on optical glucose measurements in an animal model

M. Rumpler, M. Hajnsek, P. Baumann, T. R. Pieber, I. Klimant

Publikation: Beitrag in einer FachzeitschriftShort communicationForschungBegutachtung

Abstract

The purpose of this study was to characterize the heterogeneity of oxygen partial pressure in different adipose tissue zones and to assess the possibility of compensating these heterogeneities during optical glucose measurements. In this proof of concept study, the heterogeneity of oxygen partial pressure was determined in the adipose tissue of a pig by using 48 oxygen sensors in 3 zones of the abdominal region at two different blood oxygen levels. Sensor oxygen values correlated well with reference blood oxygen values and we identified heterogeneities in oxygen partial pressure among the defined zones of the abdominal region. Significant differences in the mean oxygen partial pressure were found when comparing the three abdominal zones but no significant differences were found when comparing two sensors located in close proximity (on one cannula). The low heterogeneity on one cannula allows the compensation of physiological oxygen variations for optical glucose measurements by using an additional oxygen sensor in close proximity to the glucose sensor. In addition, this setup can be used to continuously monitor tissue oxygenation e.g. in patients with adipose tissue dysfunction or serve limb ischemia.

Originalspracheenglisch
Seiten (von - bis)583-586
Seitenumfang4
FachzeitschriftJournal of Clinical Monitoring and Computing
Jahrgang32
Ausgabenummer3
DOIs
PublikationsstatusVeröffentlicht - 1 Jun 2018

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Animal Models
Oxygen
Glucose
Partial Pressure
Adipose Tissue
Swine
Ischemia
Extremities

Schlagwörter

    ASJC Scopus subject areas

    • !!Health Informatics
    • !!Critical Care and Intensive Care Medicine
    • !!Anesthesiology and Pain Medicine

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    Monitoring tissue oxygen heterogeneities and their influence on optical glucose measurements in an animal model. / Rumpler, M.; Hajnsek, M.; Baumann, P.; Pieber, T. R.; Klimant, I.

    in: Journal of Clinical Monitoring and Computing, Jahrgang 32, Nr. 3, 01.06.2018, S. 583-586.

    Publikation: Beitrag in einer FachzeitschriftShort communicationForschungBegutachtung

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    AU - Hajnsek, M.

    AU - Baumann, P.

    AU - Pieber, T. R.

    AU - Klimant, I.

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    KW - Optical oxygen sensor

    KW - Oxygen distribution

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