MOFBOTS: Metal–Organic-Framework-Based Biomedical Microrobots

Xiaopu Wang, Xiang Zhong Chen, Carlos C.J. Alcântara, Semih Sevim, Marcus Hoop, Anastasia Terzopoulou, Carmela de Marco, Chengzhi Hu, Andrew J. de Mello, Paolo Falcaro, Shuhei Furukawa, Bradley J. Nelson, Josep Puigmartí-Luis, Salvador Pané

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Motile metal−organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.

Originalspracheenglisch
Aufsatznummer1901592
FachzeitschriftAdvanced Materials
Jahrgang31
Ausgabenummer27
DOIs
PublikationsstatusVeröffentlicht - 5 Jul 2019

Schlagwörter

    ASJC Scopus subject areas

    • !!Materials Science(all)
    • !!Mechanics of Materials
    • !!Mechanical Engineering

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  • Dieses zitieren

    Wang, X., Chen, X. Z., Alcântara, C. C. J., Sevim, S., Hoop, M., Terzopoulou, A., ... Pané, S. (2019). MOFBOTS: Metal–Organic-Framework-Based Biomedical Microrobots. Advanced Materials, 31(27), [1901592]. https://doi.org/10.1002/adma.201901592