Modified Stöber synthesis of highly luminescent dye-doped silica nanoparticles

G. Canton, R. Ricco, F. Marinello, S. Carmignato, F. Enrichi

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Dye-doped silica nanoparticles (NPs) have been demonstrated to be sensitive labeling markers for biosensing and bioimaging. Their flexible conjugation, excellent photostability and ultrasensitivity make them a powerful tool in biological analysis. Although there have been many reports on the basic research and application of these NPs, they are far from reaching their full potential. Silica NPs can be obtained through two principal approaches: the Stöber synthesis and the microemulsion method. The Stöber synthesis has the advantage of being easily scaled up for commercial applications and the possibility to effortlessly transfer the NPs into aqueous solutions (typical of bioanalysis). However, further investigation on the impact of the synthesis parameters on the particles size and on the doping process are needed in order to obtain highly luminescent particles. In this study a modified Stöber synthesis is proposed and a systematic study of the different reagents is reported, which provides a better picture on the influence of ethanol, ammonia, water, silica precursors, and dye concentration on the final morpho-optical properties. As a result, samples of luminescent silica NPs from 10 to 300 nm have been synthesized and optimized to be highly promising labels for biological applications.

Originalspracheenglisch
Seiten (von - bis)4349-4356
Seitenumfang8
FachzeitschriftJournal of Nanoparticle Research
Jahrgang13
Ausgabenummer9
DOIs
PublikationsstatusVeröffentlicht - Sep 2011
Extern publiziertJa

Fingerprint

Dyes
Silica
Silicon Dioxide
Nanoparticles
Coloring Agents
dyes
Synthesis
silicon dioxide
nanoparticles
synthesis
Microemulsion
Biosensing
bioassay
Ammonia
Microemulsions
Ethanol
Conjugation
conjugation
Particle Size
Precursor

Schlagwörter

    ASJC Scopus subject areas

    • !!Atomic and Molecular Physics, and Optics
    • !!Condensed Matter Physics
    • !!Modelling and Simulation
    • !!Chemistry(all)
    • !!Materials Science(all)
    • Bioengineering

    Dies zitieren

    Modified Stöber synthesis of highly luminescent dye-doped silica nanoparticles. / Canton, G.; Ricco, R.; Marinello, F.; Carmignato, S.; Enrichi, F.

    in: Journal of Nanoparticle Research, Jahrgang 13, Nr. 9, 09.2011, S. 4349-4356.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    Canton, G. ; Ricco, R. ; Marinello, F. ; Carmignato, S. ; Enrichi, F. / Modified Stöber synthesis of highly luminescent dye-doped silica nanoparticles. in: Journal of Nanoparticle Research. 2011 ; Jahrgang 13, Nr. 9. S. 4349-4356.
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