Modeling external stimulation of excitable cells using a novel light-activated organic semiconductor technology

Sara Stoppacher*, Susanne Scheruebel, Muammer Üçal, Karin Kornmüller, Eric Głowacki, Rainer Schindl, Niroj Shrestha, Tony Schmidt, Christian Baumgartner, Theresa Margarethe Rienmüller

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in Buch/Bericht/KonferenzbandBeitrag in einem Konferenzband

Abstract

Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.
Originalspracheenglisch
TiteldHealth 2020 - Biomedical Informatics for Health and Care
UntertitelProceedings of the 14th Health Informatics Meets Digital Health Conference
Redakteure/-innenGunter Schreier, Dieter Hayn, Alphons Eggerth
Seiten9-16
Seitenumfang8
Band271
ISBN (elektronisch)9781643680842
DOIs
PublikationsstatusVeröffentlicht - 23 Jun 2020
VeranstaltungdHealth 2020 - Wien, Österreich
Dauer: 19 Mai 202020 Mai 2020

Publikationsreihe

NameStudies in Health Technology and Informatics
Band271
ISSN (Print)0926-9630
ISSN (elektronisch)1879-8365

Konferenz

KonferenzdHealth 2020
LandÖsterreich
OrtWien
Zeitraum19/05/2020/05/20

ASJC Scopus subject areas

  • !!Health Information Management
  • !!Health Informatics
  • !!Biomedical Engineering

Fields of Expertise

  • Human- & Biotechnology

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