Modeling external stimulation of excitable cells using a novel light-activated organic semiconductor technology

Sara Stoppacher, Susanne Scheruebel, Muammer Üçal, Karin Kornmüller, Eric Głowacki, Rainer Schindl, Niroj Shrestha, Tony Schmidt, Christian Baumgartner, Theresa Margarethe Rienmüller

Publikation: Beitrag in Buch/Bericht/KonferenzbandBeitrag in einem KonferenzbandForschungBegutachtung

Abstract

Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.
Originalspracheenglisch
Titel Stud Health Technol Inform
UntertiteldHealth 2020 – Biomedical Informatics for Health and Care
Seiten9-16
Seitenumfang8
Band271
DOIs
PublikationsstatusAngenommen/In Druck - 2020
VeranstaltungdHealth 2020 - Wien, Österreich
Dauer: 19 Mai 202020 Mai 2020

Konferenz

KonferenzdHealth 2020
LandÖsterreich
OrtWien
Zeitraum19/05/2020/05/20

Schlagwörter

    Fields of Expertise

    • Human- & Biotechnology

    Fingerprint Untersuchen Sie die Forschungsthemen von „Modeling external stimulation of excitable cells using a novel light-activated organic semiconductor technology“. Zusammen bilden sie einen einzigartigen Fingerprint.

  • Dieses zitieren

    Stoppacher, S., Scheruebel, S., Üçal, M., Kornmüller, K., Głowacki, E., Schindl, R., ... Rienmüller, T. M. (Angenommen/Im Druck). Modeling external stimulation of excitable cells using a novel light-activated organic semiconductor technology. in Stud Health Technol Inform : dHealth 2020 – Biomedical Informatics for Health and Care (Band 271, S. 9-16) https://doi.org/10.3233/SHTI200068