Abstract
A set of S-adenosyl-l-methionine (SAM) dependent methyltransferases has been characterized as versatile catalysts for the enzymatic Friedel-Crafts (alkylation) reaction. Although the substrate specificity of the enzymes range from high (in the case of SfmM2, SacF, and ORF19) to moderate (in the case of NovO and CouO), the cofactor spectrum is broad. Modified cofactors decorated with alkyl groups other than methyl were used for biocatalytic Friedel-Crafts alkylation, and conversions up to 99 % were achieved. In contrast to the classical chemical reaction the biotransformation is very selective and environmentally compatible. Arts and Friedel-Crafts: A set of S-adenosyl-l-methionine (SAM) dependent methyltransferases as versatile catalysts for the enzymatic Friedel-Crafts (alkylation) reaction is characterized. Modified cofactors decorated with alkyl groups other than methyl are used for biocatalytic Friedel-Crafts alkylation, and conversions up to 99 % are achieved. In contrast to the classical chemical reaction the biotransformation is very selective and environmentally compatible.
| Originalsprache | englisch |
|---|---|
| Seiten (von - bis) | 1354-1360 |
| Seitenumfang | 7 |
| Fachzeitschrift | ChemCatChem |
| Jahrgang | 8 |
| Ausgabenummer | 7 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 6 Apr 2016 |
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ASJC Scopus subject areas
- Organische Chemie
- !!Physical and Theoretical Chemistry
- !!Catalysis
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Methyltransferases : Green Catalysts for Friedel-Crafts Alkylations. / Tengg, Martin; Stecher, Harald; Offner, Lisa; Plasch, Katharina; Anderl, Felix; Weber, Hansjörg; Schwab, Helmut; Gruber, Mandana.
in: ChemCatChem, Jahrgang 8, Nr. 7, 06.04.2016, S. 1354-1360.Publikation: Beitrag in einer Fachzeitschrift › Artikel › Forschung › Begutachtung
}
TY - JOUR
T1 - Methyltransferases
T2 - Green Catalysts for Friedel-Crafts Alkylations
AU - Tengg, Martin
AU - Stecher, Harald
AU - Offner, Lisa
AU - Plasch, Katharina
AU - Anderl, Felix
AU - Weber, Hansjörg
AU - Schwab, Helmut
AU - Gruber, Mandana
PY - 2016/4/6
Y1 - 2016/4/6
N2 - A set of S-adenosyl-l-methionine (SAM) dependent methyltransferases has been characterized as versatile catalysts for the enzymatic Friedel-Crafts (alkylation) reaction. Although the substrate specificity of the enzymes range from high (in the case of SfmM2, SacF, and ORF19) to moderate (in the case of NovO and CouO), the cofactor spectrum is broad. Modified cofactors decorated with alkyl groups other than methyl were used for biocatalytic Friedel-Crafts alkylation, and conversions up to 99 % were achieved. In contrast to the classical chemical reaction the biotransformation is very selective and environmentally compatible. Arts and Friedel-Crafts: A set of S-adenosyl-l-methionine (SAM) dependent methyltransferases as versatile catalysts for the enzymatic Friedel-Crafts (alkylation) reaction is characterized. Modified cofactors decorated with alkyl groups other than methyl are used for biocatalytic Friedel-Crafts alkylation, and conversions up to 99 % are achieved. In contrast to the classical chemical reaction the biotransformation is very selective and environmentally compatible.
AB - A set of S-adenosyl-l-methionine (SAM) dependent methyltransferases has been characterized as versatile catalysts for the enzymatic Friedel-Crafts (alkylation) reaction. Although the substrate specificity of the enzymes range from high (in the case of SfmM2, SacF, and ORF19) to moderate (in the case of NovO and CouO), the cofactor spectrum is broad. Modified cofactors decorated with alkyl groups other than methyl were used for biocatalytic Friedel-Crafts alkylation, and conversions up to 99 % were achieved. In contrast to the classical chemical reaction the biotransformation is very selective and environmentally compatible. Arts and Friedel-Crafts: A set of S-adenosyl-l-methionine (SAM) dependent methyltransferases as versatile catalysts for the enzymatic Friedel-Crafts (alkylation) reaction is characterized. Modified cofactors decorated with alkyl groups other than methyl are used for biocatalytic Friedel-Crafts alkylation, and conversions up to 99 % are achieved. In contrast to the classical chemical reaction the biotransformation is very selective and environmentally compatible.
KW - alkylation
KW - biocatalysis
KW - C-C bond formation
KW - enzymes
KW - green chemistry
UR - http://www.scopus.com/inward/record.url?scp=84959432665&partnerID=8YFLogxK
U2 - 10.1002/cctc.201501306
DO - 10.1002/cctc.201501306
M3 - Article
VL - 8
SP - 1354
EP - 1360
JO - ChemCatChem
JF - ChemCatChem
SN - 1867-3880
IS - 7
ER -