TY - JOUR
T1 - Mechanics of Porcine Heart Valves' Strut Chordae Tendineae Investigated as a Leaflet-Chordae-Papillary Muscle Entity
AU - Ross, Colton J
AU - Laurence, Devin W
AU - Hsu, Ming-Chen
AU - Baumwart, Ryan
AU - Zhao, Yan D
AU - Mir, Arshid
AU - Burkhart, Harold M
AU - Holzapfel, Gerhard A
AU - Wu, Yi
AU - Lee, Chung-Hao
PY - 2020/5
Y1 - 2020/5
N2 - Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as individual structures, usually in a clamping-based approach, which may not accurately reflect the in vivo chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet-chordae-papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09-1.16, while peak stretches of 1.08-1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease.
AB - Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as individual structures, usually in a clamping-based approach, which may not accurately reflect the in vivo chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet-chordae-papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09-1.16, while peak stretches of 1.08-1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease.
KW - Animals
KW - Biomechanical Phenomena
KW - Chordae Tendineae/physiology
KW - Mitral Valve/physiology
KW - Papillary Muscles/physiology
KW - Swine
KW - Tricuspid Valve/physiology
KW - Chordae tendineae mechanics
KW - The tricuspid valve
KW - Uniaxial mechanical testing
KW - The mitral valve
KW - Constitutive modeling
UR - http://www.scopus.com/inward/record.url?scp=85078838447&partnerID=8YFLogxK
U2 - 10.1007/s10439-020-02464-6
DO - 10.1007/s10439-020-02464-6
M3 - Article
C2 - 32006267
SN - 0090-6964
VL - 48
SP - 1463
EP - 1474
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - 5
ER -