(R)-Selective amination

Martin Schurmann (Erfinder), Wijnand Peter Helena Peeters (Erfinder), Natascha Hubertina Johannes Smeets (Erfinder), Helmut Schwab (Erfinder), Kerstin Steiner (Erfinder), Kateryna Fesko (Erfinder), Gernot Strohmeier (Erfinder)

Publikation: SchutzrechtPatentForschung

Abstract

The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.
Originalspracheenglisch
VeröffentlichungsnummerWO2012007548
IPCC12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00
Prioritätsdatum14/07/10
PublikationsstatusVeröffentlicht - 19 Jan 2012

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Amination
Transaminases
Patents and inventions
Ketones
Microorganisms
Amines
Proteins

Schlagwörter

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    Schurmann, M., Peeters, W. P. H., Smeets, N. H. J., Schwab, H., Steiner, K., Fesko, K., & Strohmeier, G. (2012). IPC Nr. C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. (R)-Selective amination. (Patent Nr. WO2012007548).

    (R)-Selective amination. / Schurmann, Martin (Erfinder); Peeters, Wijnand Peter Helena (Erfinder); Smeets, Natascha Hubertina Johannes (Erfinder); Schwab, Helmut (Erfinder); Steiner, Kerstin (Erfinder); Fesko, Kateryna (Erfinder); Strohmeier, Gernot (Erfinder).

    IPC Nr.: C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. Patent Nr.: WO2012007548.

    Publikation: SchutzrechtPatentForschung

    Schurmann, M, Peeters, WPH, Smeets, NHJ, Schwab, H, Steiner, K, Fesko, K & Strohmeier, G 2012, (R)-Selective amination, Patent Nr. WO2012007548, IPC Nr. C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00.
    Schurmann M, Peeters WPH, Smeets NHJ, Schwab H, Steiner K, Fesko K et al, Erfinder/-innen. (R)-Selective amination. C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. 2012 Jan 19.
    Schurmann, Martin (Erfinder) ; Peeters, Wijnand Peter Helena (Erfinder) ; Smeets, Natascha Hubertina Johannes (Erfinder) ; Schwab, Helmut (Erfinder) ; Steiner, Kerstin (Erfinder) ; Fesko, Kateryna (Erfinder) ; Strohmeier, Gernot (Erfinder). / (R)-Selective amination. IPC Nr.: C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. Patent Nr.: WO2012007548.
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    title = "(R)-Selective amination",
    abstract = "The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.",
    keywords = "Transaminase, Transamination",
    author = "Martin Schurmann and Peeters, {Wijnand Peter Helena} and Smeets, {Natascha Hubertina Johannes} and Helmut Schwab and Kerstin Steiner and Kateryna Fesko and Gernot Strohmeier",
    year = "2012",
    month = "1",
    day = "19",
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    type = "Patent",
    note = "WO2012007548; C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00",

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    TY - PAT

    T1 - (R)-Selective amination

    AU - Schurmann, Martin

    AU - Peeters, Wijnand Peter Helena

    AU - Smeets, Natascha Hubertina Johannes

    AU - Schwab, Helmut

    AU - Steiner, Kerstin

    AU - Fesko, Kateryna

    AU - Strohmeier, Gernot

    PY - 2012/1/19

    Y1 - 2012/1/19

    N2 - The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.

    AB - The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.

    KW - Transaminase

    KW - Transamination

    M3 - Patent

    M1 - WO2012007548

    ER -