TY - JOUR
T1 - Iminosugars and relatives as antiviral and potential anti-infective agents
AU - Greimel, Peter
AU - Spreitz, Josef
AU - Stütz, Arnold
AU - Wrodnigg, Tanja
PY - 2003
Y1 - 2003
N2 - Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.
AB - Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.
KW - Animals
KW - Anti-Infective Agents/chemistry
KW - Antiprotozoal Agents/chemical synthesis
KW - Antiviral Agents/chemistry
KW - Enzyme Inhibitors/chemistry
KW - Humans
KW - Monosaccharides/chemistry
U2 - 10.2174/1568026033452456
DO - 10.2174/1568026033452456
M3 - Review article
C2 - 12570863
SN - 1568-0266
VL - 3
SP - 513
EP - 523
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 5
ER -