High-Field Detection of Biomarkers with Fast Field-Cycling MRI: The Example of Zinc Sensing

Markus Bödenler, Kyangwi P. Malikidogo, Jean François Morfin, Christoph Stefan Aigner, Éva Tóth, Célia S. Bonnet, Hermann Scharfetter

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Many smart magnetic resonance imaging (MRI) probes provide response to a biomarker based on modulation of their rotational correlation time. The magnitude of such MRI signal changes is highly dependent on the magnetic field and the response decreases dramatically at high fields (>2 T). To overcome the loss of efficiency of responsive probes at high field, with fast-field cycling magnetic resonance imaging (FFC-MRI) we exploit field-dependent information rather than the absolute difference in the relaxation rate measured in the absence and in the presence of the biomarker at a given imaging field. We report here the application of fast field-cycling techniques combined with the use of a molecular probe for the detection of Zn2+ to achieve 166 % MRI signal enhancement at 3 T, whereas the same agent provides no detectable response using conventional MRI. This approach can be generalized to any biomarker provided the detection is based on variation of the rotational motion of the probe.

Originalspracheenglisch
Seiten (von - bis)8236-8239
Seitenumfang4
FachzeitschriftChemistry - a European Journal
Jahrgang25
Ausgabenummer35
DOIs
PublikationsstatusVeröffentlicht - 21 Jun 2019

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Biomarkers
Magnetic resonance
Zinc
Imaging techniques
Molecular Probes
Modulation
Magnetic fields

Schlagwörter

    ASJC Scopus subject areas

    • !!Catalysis
    • !!Chemistry(all)
    • Organische Chemie

    Fields of Expertise

    • Human- & Biotechnology

    Dies zitieren

    High-Field Detection of Biomarkers with Fast Field-Cycling MRI : The Example of Zinc Sensing. / Bödenler, Markus; Malikidogo, Kyangwi P.; Morfin, Jean François; Aigner, Christoph Stefan; Tóth, Éva; Bonnet, Célia S.; Scharfetter, Hermann.

    in: Chemistry - a European Journal, Jahrgang 25, Nr. 35, 21.06.2019, S. 8236-8239.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    Bödenler, Markus ; Malikidogo, Kyangwi P. ; Morfin, Jean François ; Aigner, Christoph Stefan ; Tóth, Éva ; Bonnet, Célia S. ; Scharfetter, Hermann. / High-Field Detection of Biomarkers with Fast Field-Cycling MRI : The Example of Zinc Sensing. in: Chemistry - a European Journal. 2019 ; Jahrgang 25, Nr. 35. S. 8236-8239.
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    AU - Morfin, Jean François

    AU - Aigner, Christoph Stefan

    AU - Tóth, Éva

    AU - Bonnet, Célia S.

    AU - Scharfetter, Hermann

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