TY - JOUR
T1 - High-Field Detection of Biomarkers with Fast Field-Cycling MRI
T2 - The Example of Zinc Sensing
AU - Bödenler, Markus
AU - Malikidogo, Kyangwi P.
AU - Morfin, Jean François
AU - Aigner, Christoph Stefan
AU - Tóth, Éva
AU - Bonnet, Célia S.
AU - Scharfetter, Hermann
PY - 2019/6/21
Y1 - 2019/6/21
N2 - Many smart magnetic resonance imaging (MRI) probes provide response to a biomarker based on modulation of their rotational correlation time. The magnitude of such MRI signal changes is highly dependent on the magnetic field and the response decreases dramatically at high fields (>2 T). To overcome the loss of efficiency of responsive probes at high field, with fast-field cycling magnetic resonance imaging (FFC-MRI) we exploit field-dependent information rather than the absolute difference in the relaxation rate measured in the absence and in the presence of the biomarker at a given imaging field. We report here the application of fast field-cycling techniques combined with the use of a molecular probe for the detection of Zn2+ to achieve 166 % MRI signal enhancement at 3 T, whereas the same agent provides no detectable response using conventional MRI. This approach can be generalized to any biomarker provided the detection is based on variation of the rotational motion of the probe.
AB - Many smart magnetic resonance imaging (MRI) probes provide response to a biomarker based on modulation of their rotational correlation time. The magnitude of such MRI signal changes is highly dependent on the magnetic field and the response decreases dramatically at high fields (>2 T). To overcome the loss of efficiency of responsive probes at high field, with fast-field cycling magnetic resonance imaging (FFC-MRI) we exploit field-dependent information rather than the absolute difference in the relaxation rate measured in the absence and in the presence of the biomarker at a given imaging field. We report here the application of fast field-cycling techniques combined with the use of a molecular probe for the detection of Zn2+ to achieve 166 % MRI signal enhancement at 3 T, whereas the same agent provides no detectable response using conventional MRI. This approach can be generalized to any biomarker provided the detection is based on variation of the rotational motion of the probe.
KW - contrast agents
KW - fast field-cycling
KW - high-field detection
KW - magnetic resonance imaging
KW - molecular imaging
UR - http://www.scopus.com/inward/record.url?scp=85066884064&partnerID=8YFLogxK
U2 - 10.1002/chem.201901157
DO - 10.1002/chem.201901157
M3 - Article
C2 - 30990914
AN - SCOPUS:85066884064
SN - 0947-6539
VL - 25
SP - 8236
EP - 8239
JO - Chemistry - a European Journal
JF - Chemistry - a European Journal
IS - 35
ER -