Global small-angle scattering data analysis of inverted hexagonal phases

Moritz P.K. Frewein, Michael Rumetshofer, Georg Pabst*

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikel


A global analysis model has been developed for randomly oriented, fully hydrated, inverted hexagonal (H II ) phases formed by many amphiphiles in aqueous solution, including membrane lipids. The model is based on a structure factor for hexagonally packed rods and a compositional model for the scattering length density, enabling also the analysis of positionally weakly correlated H II phases. Bayesian probability theory was used for optimization of the adjustable parameters, which allows parameter correlations to be retrieved in much more detail than standard analysis techniques and thereby enables a realistic error analysis. The model was applied to different phosphatidylethanolamines, including previously unreported H II data for diC14:0 and diC16:1 phosphatidylethanolamine. The extracted structural features include intrinsic lipid curvature, hydrocarbon chain length and area per lipid at the position of the neutral plane.

Seiten (von - bis)403-414
FachzeitschriftJournal of Applied Crystallography
PublikationsstatusVeröffentlicht - 1 Apr 2019

ASJC Scopus subject areas

  • !!Biochemistry, Genetics and Molecular Biology(all)


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