Functionalization of microarray devices: Process optimization using a multiobjective PSO and multiresponse MARS modeling

Laura Villanova, Paolo Falcaro, Davide Carta, Irene Poli, Rob Hyndman, Kate Smith-Miles

Publikation: Beitrag in Buch/Bericht/KonferenzbandBeitrag in einem KonferenzbandForschungBegutachtung

Abstract

An evolutionary approach for the optimization of microarray coatings produced via sol-gel chemistry is presented. The aim of the methodology is to face the challenging aspects of the problem: unknown objective function, high dimensional variable space, constraints on the independent variables, multiple responses, expensive or time-consuming experimental trials, expected complexity of the functional relationships between independent and response variables. The proposed approach iteratively selects a set of experiments by combining a multiob-jective Particle Swarm Optimization (PSO) and a multiresponse Multivariate Adaptive Regression Splines (MARS) model. At each iteration of the algorithm the selected experiments are implemented and evaluated, and the system response is used as a feedback for the selection of the new trials. The performance of the approach is measured in terms of improvements with respect to the best coating obtained changing one variable at a time (the method typically used by scientists). Relevant enhancements have been detected, and the proposed evolutionary approach is shown to be a useful methodology for process optimization with great promise for industrial applications.

Originalspracheenglisch
Titel2010 IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010
DOIs
PublikationsstatusVeröffentlicht - 2010
Extern publiziertJa
Veranstaltung2010 6th IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010 - Barcelona, Spanien
Dauer: 18 Jul 201023 Jul 2010

Konferenz

Konferenz2010 6th IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010
LandSpanien
OrtBarcelona
Zeitraum18/07/1023/07/10

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ASJC Scopus subject areas

  • !!Computational Theory and Mathematics
  • Angewandte Mathematik

Dieses zitieren

Villanova, L., Falcaro, P., Carta, D., Poli, I., Hyndman, R., & Smith-Miles, K. (2010). Functionalization of microarray devices: Process optimization using a multiobjective PSO and multiresponse MARS modeling. in 2010 IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010 [5586165] https://doi.org/10.1109/CEC.2010.5586165