Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal–Organic Frameworks

Weibin Liang, Huoshu Xu, Francesco Carraro, Natasha K. Maddigan, Qiaowei Li, Stephen G. Bell, David M. Huang, Andrew Tarzia, Marcello B. Solomon, Heinz Amenitsch, Lisa Vaccari, Christopher J. Sumby, Paolo Falcaro, Christian J. Doonan

Publikation: Beitrag in einer FachzeitschriftArtikel

Abstract

Encapsulation of biomacromolecules in metal–organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.
Originalspracheenglisch
Seiten (von - bis)2348-2355
FachzeitschriftJournal of the American Chemical Society
Jahrgang141
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - 12 Jan 2019

ASJC Scopus subject areas

  • !!Chemistry(all)
  • !!Biochemistry
  • !!Catalysis
  • !!Colloid and Surface Chemistry

Fields of Expertise

  • Advanced Materials Science

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