Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds

Birgit Grill (Erfinder), Margit Winkler (Erfinder), Helmut Schwab (Erfinder), Gernot Strohmeier (Erfinder), Kai Donsbach (Erfinder), Siegfried R. Waldvogel (Erfinder), Sebastian Arndt (Erfinder), Dominik Weis (Erfinder)

Publikation: SchutzrechtPatent

Abstract

he present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as further improved NHase enzyme mutants, nucleic acid molecules encoding these enzymes, recombinant microorganisms suitable for preparing such enzymes and mutants. Another aspect of the invention relates to a chemo-biocatalytic process for the preparation of lactam compounds comprising the new catalytic process for the preparation of alpha amino amide compounds catalyzed by NHase enzymes, as well as the chemical oxidation of the alpha amino amide by applying certain chemical oxidation catalysts suitable for converting the alpha amino amide under retention of its stereochemical configuration to the respective lactam. The novel chemobiocatalytic process is particularly suited for the synthesis of valuable pharmaceutical compounds, like in particular (S)-Levetiracetam.
Originalspracheenglisch
VeröffentlichungsnummerWO2021/214283 A1
Prioritätsdatum24/04/20
PublikationsstatusVeröffentlicht - 28 Okt 2021

Fields of Expertise

  • Human- & Biotechnology

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