Development of a generic process model for membrane adsorption

Peter van Beijeren, Peter Kreis, Tim Zeiner

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

In this work, a generic model describing the dynamic adsorption behaviour of proteins on membrane adsorbers over complete purification cycles under consideration of module geometry and of the interaction between multiple transport mechanisms is developed.A general rate model for membrane adsorption, in which the interaction between multiple phenomena, like mass transfer and adsorption kinetics are considered, is formulated. Hereby, the implemented isotherms describe the influence of eluting agents on the adsorption behaviour, so that complete purification cycle (loading, washing and elution operation) can be simulated.Using the developed model the theoretical influence of relevant transport phenomena, operating conditions and process scale on affinity and ion exchange membrane adsorption of proteins are investigated. An example on ion exchange membrane adsorption illustrates the possibility to predict scale up effects occurring in configurations of multiple membrane adsorber modules. The obtained simulation results are in accordance with experimental observations reported in literature.

Originalspracheenglisch
Seiten (von - bis)86-101
Seitenumfang16
FachzeitschriftComputers & chemical engineering
Jahrgang53
DOIs
PublikationsstatusVeröffentlicht - 1 Jun 2013

Fingerprint

Membranes
Adsorption
Ion exchange membranes
Purification
Proteins
Washing
Isotherms
Mass transfer
Kinetics
Geometry

Schlagwörter

    ASJC Scopus subject areas

    • !!Chemical Engineering(all)
    • !!Computer Science Applications

    Dies zitieren

    Development of a generic process model for membrane adsorption. / van Beijeren, Peter; Kreis, Peter; Zeiner, Tim.

    in: Computers & chemical engineering, Jahrgang 53, 01.06.2013, S. 86-101.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    van Beijeren, Peter ; Kreis, Peter ; Zeiner, Tim. / Development of a generic process model for membrane adsorption. in: Computers & chemical engineering. 2013 ; Jahrgang 53. S. 86-101.
    @article{61db0c05f4a6450fb0c9fdc0a5ea291f,
    title = "Development of a generic process model for membrane adsorption",
    abstract = "In this work, a generic model describing the dynamic adsorption behaviour of proteins on membrane adsorbers over complete purification cycles under consideration of module geometry and of the interaction between multiple transport mechanisms is developed.A general rate model for membrane adsorption, in which the interaction between multiple phenomena, like mass transfer and adsorption kinetics are considered, is formulated. Hereby, the implemented isotherms describe the influence of eluting agents on the adsorption behaviour, so that complete purification cycle (loading, washing and elution operation) can be simulated.Using the developed model the theoretical influence of relevant transport phenomena, operating conditions and process scale on affinity and ion exchange membrane adsorption of proteins are investigated. An example on ion exchange membrane adsorption illustrates the possibility to predict scale up effects occurring in configurations of multiple membrane adsorber modules. The obtained simulation results are in accordance with experimental observations reported in literature.",
    keywords = "Affinity membrane adsorption, Ion exchange membrane adsorption, Membrane chromatography, Model based scale up, Process simulation",
    author = "{van Beijeren}, Peter and Peter Kreis and Tim Zeiner",
    year = "2013",
    month = "6",
    day = "1",
    doi = "10.1016/j.compchemeng.2013.03.005",
    language = "English",
    volume = "53",
    pages = "86--101",
    journal = "Computers & chemical engineering",
    issn = "0098-1354",
    publisher = "Elsevier B.V.",

    }

    TY - JOUR

    T1 - Development of a generic process model for membrane adsorption

    AU - van Beijeren, Peter

    AU - Kreis, Peter

    AU - Zeiner, Tim

    PY - 2013/6/1

    Y1 - 2013/6/1

    N2 - In this work, a generic model describing the dynamic adsorption behaviour of proteins on membrane adsorbers over complete purification cycles under consideration of module geometry and of the interaction between multiple transport mechanisms is developed.A general rate model for membrane adsorption, in which the interaction between multiple phenomena, like mass transfer and adsorption kinetics are considered, is formulated. Hereby, the implemented isotherms describe the influence of eluting agents on the adsorption behaviour, so that complete purification cycle (loading, washing and elution operation) can be simulated.Using the developed model the theoretical influence of relevant transport phenomena, operating conditions and process scale on affinity and ion exchange membrane adsorption of proteins are investigated. An example on ion exchange membrane adsorption illustrates the possibility to predict scale up effects occurring in configurations of multiple membrane adsorber modules. The obtained simulation results are in accordance with experimental observations reported in literature.

    AB - In this work, a generic model describing the dynamic adsorption behaviour of proteins on membrane adsorbers over complete purification cycles under consideration of module geometry and of the interaction between multiple transport mechanisms is developed.A general rate model for membrane adsorption, in which the interaction between multiple phenomena, like mass transfer and adsorption kinetics are considered, is formulated. Hereby, the implemented isotherms describe the influence of eluting agents on the adsorption behaviour, so that complete purification cycle (loading, washing and elution operation) can be simulated.Using the developed model the theoretical influence of relevant transport phenomena, operating conditions and process scale on affinity and ion exchange membrane adsorption of proteins are investigated. An example on ion exchange membrane adsorption illustrates the possibility to predict scale up effects occurring in configurations of multiple membrane adsorber modules. The obtained simulation results are in accordance with experimental observations reported in literature.

    KW - Affinity membrane adsorption

    KW - Ion exchange membrane adsorption

    KW - Membrane chromatography

    KW - Model based scale up

    KW - Process simulation

    UR - http://www.scopus.com/inward/record.url?scp=84875762627&partnerID=8YFLogxK

    U2 - 10.1016/j.compchemeng.2013.03.005

    DO - 10.1016/j.compchemeng.2013.03.005

    M3 - Article

    VL - 53

    SP - 86

    EP - 101

    JO - Computers & chemical engineering

    JF - Computers & chemical engineering

    SN - 0098-1354

    ER -