Design of anticoagulant surfaces based on cellulose nanocrystals

Heike Ehmann; Tamilselvan Mohan; Maria Koshanskaya; Sylvia Scheicher; Doris Breitwieser; Volker Ribitsch; Karin Stana-Kleinschek; Stefan Spirk

doi:10.1039/c4cc05254d

Design of anticoagulant surfaces based on cellulose nanocrystals

Heike Ehmann^*, Tamilselvan Mohan, Maria Koshanskaya, Sylvia Scheicher, Doris Breitwieser, Volker Ribitsch, Karin Stana-Kleinschek, Stefan Spirk^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Chemische Technologie von Materialien (6380)

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.

Originalsprache	englisch
Seiten (von - bis)	13070-13072
Fachzeitschrift	Chemical Communications
Jahrgang	50
Ausgabenummer	86
DOIs	https://doi.org/10.1039/c4cc05254d
Publikationsstatus	Veröffentlicht - 2014

Fields of Expertise

Advanced Materials Science

Treatment code (Nähere Zuordnung)

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10.1039/c4cc05254d

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title = "Design of anticoagulant surfaces based on cellulose nanocrystals",

abstract = "The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.",

author = "Heike Ehmann and Tamilselvan Mohan and Maria Koshanskaya and Sylvia Scheicher and Doris Breitwieser and Volker Ribitsch and Karin Stana-Kleinschek and Stefan Spirk",

year = "2014",

doi = "10.1039/c4cc05254d",

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AU - Ehmann, Heike

AU - Mohan, Tamilselvan

AU - Koshanskaya, Maria

AU - Scheicher, Sylvia

AU - Breitwieser, Doris

AU - Ribitsch, Volker

AU - Stana-Kleinschek, Karin

AU - Spirk, Stefan

PY - 2014

Y1 - 2014

N2 - The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.

AB - The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.

U2 - 10.1039/c4cc05254d

DO - 10.1039/c4cc05254d

M3 - Article

SN - 1364-548X

VL - 50

SP - 13070

EP - 13072

JO - Chemical Communications

JF - Chemical Communications

IS - 86

ER -

Design of anticoagulant surfaces based on cellulose nanocrystals

Abstract

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