Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Melissa Horvat; Victoria Weilch; Robert Rädisch; Sebastian Hecko; Astrid Schiefer; Florian Rudroff; Birgit Wilding; Norbert Klempier; Miroslav Patek; Ludmila Martínková; Margit Winkler

doi:10.1039/D1CY01694F

Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Melissa Horvat, Victoria Weilch, Robert Rädisch, Sebastian Hecko, Astrid Schiefer, Florian Rudroff, Birgit Wilding, Norbert Klempier, Miroslav Patek, Ludmila Martínková, Margit Winkler^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

Originalsprache	englisch
Seiten (von - bis)	62-66
Seitenumfang	5
Fachzeitschrift	Catalysis Science & Technology
Jahrgang	12
Ausgabenummer	1
DOIs	https://doi.org/10.1039/D1CY01694F
Publikationsstatus	Veröffentlicht - 7 Jan. 2022

ASJC Scopus subject areas

Katalyse

Fields of Expertise

Human- & Biotechnology

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10.1039/D1CY01694FLizenz: CC BY 4.0

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FWF - Nitriles - Neue chemoenzymatische Route von Säuren zu Nitrilen
Winkler, M.
1/03/20 → 1/08/24
Projekt: Forschungsprojekt

Dieses zitieren

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abstract = "We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.",

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AU - Horvat, Melissa

AU - Weilch, Victoria

AU - Rädisch, Robert

AU - Hecko, Sebastian

AU - Schiefer, Astrid

AU - Rudroff, Florian

AU - Wilding, Birgit

AU - Klempier, Norbert

AU - Patek, Miroslav

AU - Martínková, Ludmila

AU - Winkler, Margit

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AB - We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

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Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Abstract

ASJC Scopus subject areas

Fields of Expertise

Zugriff auf Dokument

Andere Dateien und Links

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Projekte

FWF - Nitriles - Neue chemoenzymatische Route von Säuren zu Nitrilen

Dieses zitieren