Abstract
MOFs have demonstrated outstanding properties for the protectionand controlled release of different bio-entities, from proteins toliving cells. Carbohydrates, as pure molecules or as a component ofproteins and cells, perform essential biological functions. Thus, anunderstanding of the role of carbohydrates in the formationof MOF-based bio-composites will facilitate their application tobiotechnology and medicine. Here, we investigate the role ofcarbohydrate molecular weight and chemical functionalization inthe formation of carbohydrate@MOF composites. We find thatchemical functionalization, such as carboxylation, that leads to anenhancement of metal cation concentration at the surface of themolecule triggers the rapid self-assembly of the MOF material,zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determinethe encapsulation efficiency and measure the release properties ofthe carbohydrate under controlled conditions. Our findings showthat MOFs can be used to prepare a new class of biocomposites forthe delivery of carbohydrate-based therapeutics.
Originalsprache | englisch |
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Seiten (von - bis) | 969-977 |
Seitenumfang | 9 |
Fachzeitschrift | Materials Horizons |
Jahrgang | 6 |
Ausgabenummer | 5 |
Frühes Online-Datum | 20 Feb. 2019 |
DOIs | |
Publikationsstatus | Veröffentlicht - 1 Juni 2019 |
ASJC Scopus subject areas
- Werkstoffwissenschaften (insg.)
Fields of Expertise
- Advanced Materials Science
Treatment code (Nähere Zuordnung)
- Basic - Fundamental (Grundlagenforschung)