C-5a-substituted validamine type glycosidase inhibitors.

Michael Schalli, Andreas Wolfsgruber, Andres Gonzalez Santana, Christina Tysoe, Roland Fischer, Arnold Stütz, Martin Thonhofer, Stephen G. Withers

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

A series of N-alkyl derivs. of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepd. and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases. [on SciFinder(R)]
Originalspracheenglisch
Seiten (von - bis)1-9
Seitenumfang9
FachzeitschriftCarbohydrate Research
Jahrgang440-441
DOIs
PublikationsstatusVeröffentlicht - 2017

Schlagwörter

  • aminodeoxy oligosaccharide prepn glucosidase galactosidase inhibitor validamine glycosidase

Dies zitieren

C-5a-substituted validamine type glycosidase inhibitors. / Schalli, Michael; Wolfsgruber, Andreas; Gonzalez Santana, Andres; Tysoe, Christina; Fischer, Roland; Stütz, Arnold; Thonhofer, Martin; Withers, Stephen G.

in: Carbohydrate Research, Jahrgang 440-441, 2017, S. 1-9.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Schalli, Michael ; Wolfsgruber, Andreas ; Gonzalez Santana, Andres ; Tysoe, Christina ; Fischer, Roland ; Stütz, Arnold ; Thonhofer, Martin ; Withers, Stephen G. / C-5a-substituted validamine type glycosidase inhibitors. in: Carbohydrate Research. 2017 ; Jahrgang 440-441. S. 1-9.
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abstract = "A series of N-alkyl derivs. of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepd. and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases. [on SciFinder(R)]",
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note = "M1 - Copyright (C) 2017 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2017:205636(Journal; Online Computer File)",
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T1 - C-5a-substituted validamine type glycosidase inhibitors.

AU - Schalli, Michael

AU - Wolfsgruber, Andreas

AU - Gonzalez Santana, Andres

AU - Tysoe, Christina

AU - Fischer, Roland

AU - Stütz, Arnold

AU - Thonhofer, Martin

AU - Withers, Stephen G.

N1 - M1 - Copyright (C) 2017 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2017:205636(Journal; Online Computer File)

PY - 2017

Y1 - 2017

N2 - A series of N-alkyl derivs. of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepd. and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases. [on SciFinder(R)]

AB - A series of N-alkyl derivs. of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepd. and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases. [on SciFinder(R)]

KW - aminodeoxy oligosaccharide prepn glucosidase galactosidase inhibitor validamine glycosidase

U2 - 10.1016/j.carres.2017.01.006

DO - 10.1016/j.carres.2017.01.006

M3 - Article

VL - 440-441

SP - 1

EP - 9

JO - Carbohydrate Research

JF - Carbohydrate Research

SN - 0008-6215

ER -