Biocatalytic synthesis of optically active tertiary alcohols

R Kourist, U T Bornscheuer

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

The enzymatic preparation of optically pure tertiary alcohols under sustainable conditions has received much attention. The conventional chemical synthesis of these valuable building blocks is still hampered by the use of harmful reagents such as heavy metal catalysts. Successful examples in biocatalysis used esterases, lipases, epoxide hydrolases, halohydrin dehalogenases, thiamine diphosphate-dependent enzymes, terpene cyclases, -acetylases, and -dehydratases. This mini-review provides an overview on recent developments in the discovery of new enzymes, their functional improvement by protein engineering, the design of chemoenzymatic routes leading to tertiary alcohols, and the discovery of entirely new biotransformations.

Originalspracheenglisch
Seiten (von - bis)505-17
Seitenumfang13
FachzeitschriftApplied Microbiology and Biotechnology
Jahrgang91
Ausgabenummer3
DOIs
PublikationsstatusVeröffentlicht - 2011

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Alcohols
Biocatalysis
Acetylesterase
Hydro-Lyases
Thiamine Pyrophosphate
Epoxide Hydrolases
Protein Engineering
Terpenes
Esterases
Enzymes
Biotransformation
Heavy Metals
Lipase
halohydrin dehalogenase

Schlagwörter

    Fields of Expertise

    • Human- & Biotechnology

    Dies zitieren

    Biocatalytic synthesis of optically active tertiary alcohols. / Kourist, R; Bornscheuer, U T.

    in: Applied Microbiology and Biotechnology, Jahrgang 91, Nr. 3, 2011, S. 505-17.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

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    KW - Bacteria

    KW - Biocatalysis

    KW - Hydrolases

    KW - Protein Engineering

    KW - Terpenes

    KW - Journal Article

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