Biocatalytic oxidation reactions - a Chemist's perspective

JiaJia Dong, Elena Fernández-Fueyo, Frank Hollmann, Caroline Paul, Milja Pasic, Sandy Schmidt, Yonghua Wang, Sabry Younes, Wuyuan Zhang

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.

Originalspracheenglisch
Seiten (von - bis)9238-9261
FachzeitschriftAngewandte Chemie / International Edition
Jahrgang57
Ausgabenummer30
DOIs
PublikationsstatusVeröffentlicht - Jul 2018

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Oxidation
Oxidoreductases
Enzymes
Halogenation
Redox reactions
Environmental impact
Alcohols

Schlagwörter

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    Dong, J., Fernández-Fueyo, E., Hollmann, F., Paul, C., Pasic, M., Schmidt, S., ... Zhang, W. (2018). Biocatalytic oxidation reactions - a Chemist's perspective. Angewandte Chemie / International Edition , 57(30), 9238-9261. https://doi.org/10.1002/anie.201800343

    Biocatalytic oxidation reactions - a Chemist's perspective. / Dong, JiaJia; Fernández-Fueyo, Elena; Hollmann, Frank; Paul, Caroline; Pasic, Milja; Schmidt, Sandy; Wang, Yonghua; Younes, Sabry; Zhang, Wuyuan.

    in: Angewandte Chemie / International Edition , Jahrgang 57, Nr. 30, 07.2018, S. 9238-9261.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    Dong, J, Fernández-Fueyo, E, Hollmann, F, Paul, C, Pasic, M, Schmidt, S, Wang, Y, Younes, S & Zhang, W 2018, 'Biocatalytic oxidation reactions - a Chemist's perspective' Angewandte Chemie / International Edition , Jg. 57, Nr. 30, S. 9238-9261. https://doi.org/10.1002/anie.201800343
    Dong, JiaJia ; Fernández-Fueyo, Elena ; Hollmann, Frank ; Paul, Caroline ; Pasic, Milja ; Schmidt, Sandy ; Wang, Yonghua ; Younes, Sabry ; Zhang, Wuyuan. / Biocatalytic oxidation reactions - a Chemist's perspective. in: Angewandte Chemie / International Edition . 2018 ; Jahrgang 57, Nr. 30. S. 9238-9261.
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