Biocatalytic carboxylate reduction – recent advances and new enzymes

Margit Winkler*, Jonathan Guyang Ling

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)Begutachtung

Abstract

Carboxylate reductases (CARs) are valuable catalysts for the selective one-step reduction of carboxylic acids to their corresponding aldehydes. In recent years, numerous new CARs have been made available, studied and applied in the context of biocatalytic syntheses. The preparation of aldehydes as end products for the flavor and fragrance sector and the integration of CARs in cascade reactions with aldehydes as the key intermediates represent the two major fields of applications. This review gives a comprehensive overview of the current toolbox of recombinant CARs and their numerous carboxylate substrates. Non-natural functions of CARs are highlighted and recent insight into the structure-function relationship of CARs are summarized.
Originalspracheenglisch
Aufsatznummere202200441
FachzeitschriftChemCatChem
Jahrgang14
Ausgabenummer19
DOIs
PublikationsstatusVeröffentlicht - 10 Okt. 2022

ASJC Scopus subject areas

  • Katalyse
  • Anorganische Chemie
  • Physikalische und Theoretische Chemie
  • Organische Chemie

Fields of Expertise

  • Human- & Biotechnology

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