Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation

Guan Young Jeong, Raffaele Ricco, Kang Liang, Johanna Ludwig, Jin Oh Kim, Paolo Falcaro, Dong Pyo Kim

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Functional bio-MOF hollow spheres with controlled size in the 35-2000 μm range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanoparticles (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.

Originalspracheenglisch
Seiten (von - bis)7903-7909
Seitenumfang7
FachzeitschriftChemistry of Materials
Jahrgang27
Ausgabenummer23
DOIs
PublikationsstatusVeröffentlicht - 6 Nov 2015
Extern publiziertJa

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Surface chemistry
Encapsulation
Microfluidics
Enzymes
Nanoparticles
glycerol dehydrogenase
Horseradish Peroxidase
Acetylcholinesterase
Cobalt
Glycerol
Silicon Dioxide
Catalyst activity
Silica
N(1)-methyl-2-lysergic acid diethylamide

ASJC Scopus subject areas

  • !!Materials Chemistry
  • !!Chemical Engineering(all)
  • !!Chemistry(all)

Dies zitieren

Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation. / Jeong, Guan Young; Ricco, Raffaele; Liang, Kang; Ludwig, Johanna; Kim, Jin Oh; Falcaro, Paolo; Kim, Dong Pyo.

in: Chemistry of Materials, Jahrgang 27, Nr. 23, 06.11.2015, S. 7903-7909.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Jeong, Guan Young ; Ricco, Raffaele ; Liang, Kang ; Ludwig, Johanna ; Kim, Jin Oh ; Falcaro, Paolo ; Kim, Dong Pyo. / Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation. in: Chemistry of Materials. 2015 ; Jahrgang 27, Nr. 23. S. 7903-7909.
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AU - Kim, Jin Oh

AU - Falcaro, Paolo

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