Barriers and potential solutions in the recruitment and retention of older patients in clinical trials - lessons learned from six large multicentre randomized controlled trials

Buttgereit Thomas, Andriko Palmowski, Noah Forsat, Maarten Boers, Miles D. Witham, Nicolas Rodondi, Elisavet Moutzouri, Antonio Jesus Quesada Navidad, Arnoud W J Van't Hof , Bart van der Worp, Laura Coll-Planas, Marieke Voshaar, Maarten de Wit, José da Silva, Sven Stegemann, Johannes W Bijlsma , Markus Koeller, Simon Mooijaart , Patricia M Kearney , Frank Buttgereit*

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikel

Abstract

Background
older people remain underrepresented in clinical trials, and evidence generated in younger populations cannot always be generalized to older patients.
Objective
to identify key barriers and to discuss solutions to specific issues affecting recruitment and retention of older participants in clinical trials based on experience gained from six current European randomised controlled trials (RCTs) focusing on older people.
Methods
a multidisciplinary group of experts including representatives of the six RCTs held two networking conferences and compiled lists of potential barriers and solutions. Every item was subsequently allocated points by each study team according to how important it was perceived to be for their RCTs.
Results
the six RCTs enrolled 7,612 older patients. Key barriers to recruitment were impaired health status, comorbidities and diverse health beliefs including priorities within different cultural systems. All trials had to increase the number of recruitment sites. Other measures felt to be effective included the provision of extra time, communication training for the study staff and a re-design of patient information. Key barriers for retention included the presence of severe comorbidities and the occurrence of adverse events. Long study duration, frequent study visits and difficulties accessing the study site were also mentioned. Solutions felt to be effective included spending more time maintaining close contact with the participants, appropriate measures to show appreciation and reimbursement of travel arrangements.
Conclusion
recruitment and retention of older patients in trials requires special recognition and a targeted approach. Our results provide scientifically-based practical recommendations for optimizing future studies in this population.
Originalspracheenglisch
Aufsatznummerafab147
FachzeitschriftAge and Ageing
DOIs
PublikationsstatusElektronische Veröffentlichung vor Drucklegung. - 1 Aug 2021

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