Asymmetric decarboxylation of arylmalonates and racemization of profens by arylmalonate decarboxylase and its variants

Kenji Miyamoto, Robert Kourist, Shosuke Yoshida, Hiromichi Ohta

Publikation: Konferenzbeitrag(Altdaten) Vortrag oder PräsentationForschungBegutachtung

Abstract

This article discusses the arylmalonate decarboxylase (AMDase)-catalyzed desymmetrization of α-aryl-α-Me malonic acids which gives rise to profens such as Naproxen and Flurbiprofen in up to 100% theor. yield. The racemization of profens using an AMDase mutant is also reported. It shows that the AMDase can be used for the prodn. of hydroxy acids and non-proteinogenic amino acids. [on SciFinder(R)]
Originalspracheenglisch
Seiten274-280
Seitenumfang7
PublikationsstatusVeröffentlicht - 2012

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Flurbiprofen
Naproxen
Hydroxy Acids
Amino Acids
Decarboxylation
malonate decarboxylase
malonic acid

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    Dies zitieren

    Asymmetric decarboxylation of arylmalonates and racemization of profens by arylmalonate decarboxylase and its variants. / Miyamoto, Kenji; Kourist, Robert; Yoshida, Shosuke; Ohta, Hiromichi.

    2012. 274-280.

    Publikation: Konferenzbeitrag(Altdaten) Vortrag oder PräsentationForschungBegutachtung

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    abstract = "This article discusses the arylmalonate decarboxylase (AMDase)-catalyzed desymmetrization of α-aryl-α-Me malonic acids which gives rise to profens such as Naproxen and Flurbiprofen in up to 100{\%} theor. yield. The racemization of profens using an AMDase mutant is also reported. It shows that the AMDase can be used for the prodn. of hydroxy acids and non-proteinogenic amino acids. [on SciFinder(R)]",
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    AU - Miyamoto, Kenji

    AU - Kourist, Robert

    AU - Yoshida, Shosuke

    AU - Ohta, Hiromichi

    N1 - CAPLUS AN 2012:1635684(Conference) NV - Copyright (C) 2014 American Chemical Society (ACS). All Rights Reserved.

    PY - 2012

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    N2 - This article discusses the arylmalonate decarboxylase (AMDase)-catalyzed desymmetrization of α-aryl-α-Me malonic acids which gives rise to profens such as Naproxen and Flurbiprofen in up to 100% theor. yield. The racemization of profens using an AMDase mutant is also reported. It shows that the AMDase can be used for the prodn. of hydroxy acids and non-proteinogenic amino acids. [on SciFinder(R)]

    AB - This article discusses the arylmalonate decarboxylase (AMDase)-catalyzed desymmetrization of α-aryl-α-Me malonic acids which gives rise to profens such as Naproxen and Flurbiprofen in up to 100% theor. yield. The racemization of profens using an AMDase mutant is also reported. It shows that the AMDase can be used for the prodn. of hydroxy acids and non-proteinogenic amino acids. [on SciFinder(R)]

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