TY - JOUR
T1 - Advanced therapies of skin injuries
AU - Maver, Tina
AU - Maver, Uroš
AU - Stana Kleinschek, Karin
AU - Mlinaric-Rascan, Irena
AU - Smrke, Dragica Maja
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.
AB - The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.
KW - Allograft
KW - Autograft
KW - Scaffold
KW - Tissue engineering
KW - Tissue-engineered skin
UR - http://www.scopus.com/inward/record.url?scp=84952874447&partnerID=8YFLogxK
U2 - 10.1007/s00508-015-0859-7
DO - 10.1007/s00508-015-0859-7
M3 - Review article
C2 - 26404739
AN - SCOPUS:84952874447
SN - 0043-5325
VL - 127
SP - 187
EP - 198
JO - Wiener Klinische Wochenschrift
JF - Wiener Klinische Wochenschrift
ER -