A structurally diverse library of safe-by-design citrem-phospholipid lamellar and non-lamellar liquid crystalline nano-assemblies

Intan D M Azmi, Peter P. Wibroe, Lin Ping Wu, Ali I. Kazem, Heinz Amenitsch, Seyed M. Moghimi, Anan Yaghmur

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Non-lamellar liquid crystalline aqueous nanodispersions, known also as ISAsomes (internally self-assembled ‘somes’ or nanoparticles), are gaining increasing interest in drug solubilisation and bio-imaging, but they often exhibit poor hemocompatibility and induce cytotoxicity. This limits their applications in intravenous drug delivery and targeting. Using a binary mixture of citrem and soy phosphatidylcholine (SPC) at different weight ratios, we describe a library of colloidally stable aqueous and hemocompatible nanodispersions of diverse nanoarchitectures (internal self-assembled nanostructures). This engineered library is structurally stable in human plasma as well as being hemocompatible (non-hemolytic, and poor activator of the complement system). By varying citrem to lipid weight ratio, the nanodispersion susceptibility to macrophage uptake could also be modulated. Finally, the formation of nanodispersions comprising internally V2 (inverse bicontinuous cubic) and H2 (inverse hexagonal) nanoarchitectures was achieved without the use of an organic solvent, a secondary emulsifier, or high-energy input. The tunable binary citrem/SPC nanoplatform holds promise for future development of hemocompatible and immune-safe nanopharmaceuticals.

Originalspracheenglisch
Seiten (von - bis)1-9
Seitenumfang9
FachzeitschriftJournal of Controlled Release
Jahrgang239
DOIs
PublikationsstatusVeröffentlicht - 10 Okt 2016

Schlagwörter

    ASJC Scopus subject areas

    • !!Pharmaceutical Science
    • !!Physical and Theoretical Chemistry

    Fields of Expertise

    • Human- & Biotechnology

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