A Review on 1,1-Bis(diphenylphosphino)methane bridged homo- and heterobimetallic complexes for anticancer applications: synthesis, structure, and cytotoxicity

Matylda Odachowski, Christoph Marschner, Burgert Blom

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)

Abstract

Herein, we review developments in synthesis, structure, and biological (anti-cancer) activities of 1,1-bis(diphenylphosphino)methane (dppm) bridged homo- and heterobimetallic systems of the type L mM(μ 2-dppm)M'L n (M and M′ are transition metals which may be different or the same and L n,m are co-ligands) since the first such reported bimetallic system in 1987 until the present time (2020). As the simplest diphosphine, dppm enables facile formation of bimetallic complexes, where, given the short spacer between the PPh 2 groups, close spatial proximity of the metal centres is ensured. We concentrate on complexes bearing no M–M interaction and contrast biological activities of these complexes with mononuclear counterparts and positive control agents such as cisplatin, in an attempt to elucidate patterns in the biological activities of these complexes.

Originalspracheenglisch
Aufsatznummer112613
Seitenumfang62
FachzeitschriftEuropean Journal of Medicinal Chemistry
Jahrgang204
Ausgabenummer204
DOIs
PublikationsstatusAngenommen/In Druck - 22 Jun 2020

ASJC Scopus subject areas

  • !!Drug Discovery
  • Pharmakologie
  • Organische Chemie

Fields of Expertise

  • Advanced Materials Science

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